Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8356464 | 0.91 | PTGS2 (0.47) | PLA2G2APTGS2 | |
| SCHEMBL8360160 | 0.90 | PTGS2 (0.40) | PLA2G2APTGS2 | |
| SCHEMBL8359842 | 0.88 | PTGS2 (0.47) | PLA2G2APTGS2PTGS1 | |
| SCHEMBL8361043 | 0.87 | PTGS2 (0.47) | PLA2G2APTGS2PTGS1 | |
| SCHEMBL8356407 | 0.86 | PLA2G2A (0.51) | TP53GAAPLA2G2ACNR2 | |
| SCHEMBL8356688 | 0.86 | PLA2G2A (0.54) | GAAPLA2G2A | |
| SCHEMBL8355301 | 0.82 | PTGS2 (0.45) | GAAPLA2G2APTGS2PTGS1HTR7 | |
| SCHEMBL8356739 | 0.81 | PTGS2 (0.57) | PTGS2PTGS1 | |
| SCHEMBL8360473 | 0.81 | PTGS2 (0.55) | PTGS2 | |
| SCHEMBL8354810 | 0.79 | LMNA (0.58) | PLA2G2APTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877202-A | Indole derivatives useful to treat estrogen-related neoplasms and disorders | AVENTISUB II INC. | 1999-03-02 | — | — | US | claimed |
| US-5877202-A | Indole derivatives useful to treat estrogen-related neoplasms and disorders | AVENTISUB II INC. | 1999-03-02 | — | — | US | disclosed |