Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 14/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8354405 | 0.91 | PLA2G2A (0.65) | PLA2G2AKDM4EMEN1KMT2A | |
| SCHEMBL8356688 | 0.91 | PLA2G2A (0.54) | PLA2G2AGAAALDH1A1MAPTPKM | |
| SCHEMBL8355146 | 0.89 | PLA2G2A (0.55) | PLA2G2AGAATP53MEN1KMT2A | |
| SCHEMBL8355300 | 0.86 | TP53 (0.37) | PLA2G2AGAATP53CNR2 | |
| SCHEMBL8361043 | 0.83 | PTGS2 (0.47) | PLA2G2ATSHRLMNA | |
| SCHEMBL8359842 | 0.83 | PTGS2 (0.47) | PLA2G2ATSHRLMNA | |
| SCHEMBL8356293 | 0.81 | PLA2G2A (0.61) | PLA2G2AALDH1A1MAPTPKMMEN1 | |
| SCHEMBL8356411 | 0.81 | PLA2G2A (0.49) | PLA2G2AGAAALDH1A1MAPTPKM | |
| SCHEMBL8356918 | 0.80 | PLA2G2A (0.51) | PLA2G2A | |
| SCHEMBL8361049 | 0.80 | ESR1 (0.42) | PLA2G2AGAAALDH1A1MAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877202-A | Indole derivatives useful to treat estrogen-related neoplasms and disorders | AVENTISUB II INC. | 1999-03-02 | — | — | US | claimed |
| US-5877202-A | Indole derivatives useful to treat estrogen-related neoplasms and disorders | AVENTISUB II INC. | 1999-03-02 | — | — | US | disclosed |