Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 19/20 | 0.61 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | RGS12 | O14924 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358976 | 0.93 | PLA2G2A (0.64) | PLA2G2APLA2G1BMEN1RGS12ALDH1A1 | |
| SCHEMBL8356918 | 0.92 | PLA2G2A (0.51) | PLA2G2APLA2G1B | |
| SCHEMBL8356782 | 0.92 | PLA2G2A (0.61) | PLA2G2APLA2G1BMEN1RGS12ALDH1A1 | |
| SCHEMBL8356964 | 0.92 | PLA2G2A (0.50) | PLA2G2APLA2G1B | |
| SCHEMBL8354405 | 0.91 | PLA2G2A (0.65) | PLA2G2APLA2G1BMEN1KMT2A | |
| SCHEMBL8356688 | 0.91 | PLA2G2A (0.54) | PLA2G2APLA2G1BMEN1ALDH1A1LMNA | |
| SCHEMBL8360250 | 0.88 | PLA2G2A (0.47) | PLA2G2APLA2G1BLMNACYP1A2CYP3A4 | |
| SCHEMBL8356464 | 0.86 | PTGS2 (0.47) | PLA2G2A | |
| SCHEMBL8360290 | 0.86 | PLA2G2A (0.54) | PLA2G2AALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL8354810 | 0.86 | LMNA (0.58) | PLA2G2ALMNACYP1A2CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877202-A | Indole derivatives useful to treat estrogen-related neoplasms and disorders | AVENTISUB II INC. | 1999-03-02 | — | — | US | disclosed |