Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 5/20 | 0.54 |
| ▸ | PTGS2 | P35354 | 12/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8361046 | 0.88 | PTGS2 (0.62) | PTGS2 | |
| SCHEMBL8360240 | 0.86 | PTGS2 (0.60) | PTGS2 | |
| SCHEMBL8354810 | 0.86 | LMNA (0.58) | PLA2G2APTGS2CYP1A2CYP2D6 | |
| SCHEMBL8356293 | 0.86 | PLA2G2A (0.61) | PLA2G2AALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL8354816 | 0.85 | LMNA (0.59) | PLA2G2APTGS2CYP1A2CYP2D6 | |
| SCHEMBL8354405 | 0.85 | PLA2G2A (0.65) | PLA2G2APTGS2 | |
| SCHEMBL8353887 | 0.85 | PTGS2 (0.69) | PTGS2 | |
| SCHEMBL8356464 | 0.83 | PTGS2 (0.47) | PLA2G2APTGS2 | |
| SCHEMBL8358997 | 0.82 | PTGS2 (0.56) | PTGS2 | |
| SCHEMBL8360473 | 0.82 | PTGS2 (0.55) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877202-A | Indole derivatives useful to treat estrogen-related neoplasms and disorders | AVENTISUB II INC. | 1999-03-02 | — | — | US | disclosed |