Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 13/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8360155 | 0.92 | PTGS2 (0.60) | PTGS2PTGS1 | |
| SCHEMBL8356518 | 0.92 | PTGS2 (0.49) | PTGS2PTGS1 | |
| SCHEMBL8360198 | 0.91 | PTGS2 (0.59) | PTGS2PTGS1 | |
| SCHEMBL8358919 | 0.90 | LMNA (0.61) | PTGS2LMNACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL8361043 | 0.90 | PTGS2 (0.47) | PTGS2PTGS1LMNACYP1A2CYP2D6 | |
| SCHEMBL8356848 | 0.90 | PTGS2 (0.47) | PTGS2PTGS1LMNACYP1A2CYP2D6 | |
| SCHEMBL8359842 | 0.89 | PTGS2 (0.47) | PTGS2PTGS1LMNACYP1A2CYP2D6 | |
| SCHEMBL8356449 | 0.89 | LMNA (0.50) | PTGS2PTGS1LMNACYP1A2CYP2D6 | |
| SCHEMBL8360277 | 0.84 | LMNA (0.59) | PTGS2LMNACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL8361038 | 0.82 | PTGS2 (0.64) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877202-A | Indole derivatives useful to treat estrogen-related neoplasms and disorders | AVENTISUB II INC. | 1999-03-02 | — | — | US | claimed |
| US-5877202-A | Indole derivatives useful to treat estrogen-related neoplasms and disorders | AVENTISUB II INC. | 1999-03-02 | — | — | US | disclosed |