Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.61 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.61 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 13/20 | 0.58 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.55 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8360277 | 0.94 | LMNA (0.59) | LMNACYP1A2CYP2D6CYP2C9TSHR | |
| SCHEMBL8356332 | 0.92 | PTGS2 (0.59) | PTGS2AKR1C3 | |
| SCHEMBL8356761 | 0.92 | PTGS2 (0.70) | PTGS2 | |
| SCHEMBL8356449 | 0.92 | LMNA (0.50) | LMNACYP1A2CYP2D6CYP2C9TSHR | |
| SCHEMBL8354773 | 0.91 | PTGS2 (0.71) | PTGS2 | |
| SCHEMBL8356800 | 0.90 | LMNA (0.59) | LMNACYP1A2CYP2D6CYP2C9TSHR | |
| SCHEMBL8354816 | 0.90 | LMNA (0.59) | LMNACYP1A2CYP2D6CYP2C9TSHR | |
| SCHEMBL8356338 | 0.90 | PTGS2 (0.49) | LMNACYP1A2CYP2D6CYP2C9TSHR | |
| SCHEMBL8354810 | 0.90 | LMNA (0.58) | LMNACYP1A2CYP2D6CYP2C9TSHR | |
| SCHEMBL8360017 | 0.88 | LMNA (0.62) | LMNACYP1A2CYP2D6CYP2C9TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877202-A | Indole derivatives useful to treat estrogen-related neoplasms and disorders | AVENTISUB II INC. | 1999-03-02 | — | — | US | claimed |
| US-5877202-A | Indole derivatives useful to treat estrogen-related neoplasms and disorders | AVENTISUB II INC. | 1999-03-02 | — | — | US | disclosed |