Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ELANE | P08246 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20350839 | 1.00 | HTT (0.51) | HTTHPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL19423435 | 1.00 | HTT (0.51) | HTTHPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL834473 | 0.90 | HTT (0.61) | HTTHPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL28705768 | 0.83 | HTT (0.53) | HTTHPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2844465 | 0.82 | RAB9A (0.43) | KMT2ASMN1; SMN2NPC1RAB9APOLB | |
| SCHEMBL28992358 | 0.81 | HTT (0.55) | HTTHPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2844471 | 0.80 | RAB9A (0.41) | MEN1KMT2AALDH1A1NPC1RAB9A | |
| SCHEMBL8819827 | 0.80 | PKM (0.59) | HTTHPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL2464249 | 0.80 | HTT (0.50) | HTTHPGDMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL16112824 | 0.79 | HTT (0.44) | HTTHPGDMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143423-B2 | N-heterocyclic carbene (NHC) catalyzed synthesis of hydroxamic acids | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2012-03-27 | — | — | US | disclosed |
| US-8143423-B2 | N-heterocyclic carbene (NHC) catalyzed synthesis of hydroxamic acids | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2012-03-27 | — | — | US | disclosed |
| US-8143423-B2 | N-heterocyclic carbene (NHC) catalyzed synthesis of hydroxamic acids | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2012-03-27 | — | — | US | disclosed |
| US-20100105921-A1 | N-HETEROCYCLIC CARBENE (NHC) CATALYZED SYNTHESIS OF HYDROXAMIC ACIDS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2010-04-29 | — | — | US | disclosed |
| US-20100105921-A1 | N-HETEROCYCLIC CARBENE (NHC) CATALYZED SYNTHESIS OF HYDROXAMIC ACIDS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2010-04-29 | — | — | US | disclosed |
| US-20100105921-A1 | N-HETEROCYCLIC CARBENE (NHC) CATALYZED SYNTHESIS OF HYDROXAMIC ACIDS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2010-04-29 | — | — | US | disclosed |
| WO-2008115153-A1 | N-HETEROCYCLIC CARBENE (NHC) CATALYZED SYNTHESIS OF HYDROXAMIC ACIDS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2008-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105921-A1 | N-HETEROCYCLIC CARBENE (NHC) CATALYZED SYNTHESIS OF HYDROXAMIC ACIDS | NDC1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HAO2 | HTT 104/4885HPGD 9/4885MEN1 1438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.