Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11830306 | 0.98 | HTT (0.49) | HTTHPGDACHESMN1; SMN2MEN1 | |
| SCHEMBL20268246 | 0.98 | HTT (0.51) | HTTHPGDACHESMN1; SMN2MEN1 | |
| SCHEMBL2259800 | 0.95 | HTT (0.51) | HTTHPGDACHESMN1; SMN2MEN1 | |
| SCHEMBL6429633 | 0.91 | HTT (0.59) | HTTSMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL28705768 | 0.85 | HTT (0.53) | HTTHPGDACHESMN1; SMN2MEN1 | |
| SCHEMBL28992358 | 0.83 | HTT (0.55) | HTTHPGDACHESMN1; SMN2MEN1 | |
| SCHEMBL6425135 | 0.83 | CNR2 (0.52) | HPGDSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL2592597 | 0.81 | ALDH1A1 (0.44) | SMN1; SMN2ALDH1A1POLBHDAC3HDAC1 | |
| SCHEMBL19265536 | 0.81 | CNR2 (0.50) | HPGDSMN1; SMN2MEN1KMT2ANPC1 | |
| SCHEMBL835697 | 0.80 | HTT (0.51) | HTTHPGDACHESMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2100605-B9 | Bis(thio-hydrazide amide) compounds in combination with taxol for treating cancer | SYNTA PHARMACEUTICALS CORP (US) | 2012-05-09 | — | — | EP | disclosed |
| EP-2100605-B1 | Bis(thio-hydrazide amide) compounds in combination with taxol for treating cancer | SYNTA PHARMACEUTICALS CORP (US) | 2011-09-07 | — | — | EP | disclosed |
| US-7763658-B2 | administering bis[thio-hydrazide amide] Compounds for treating multi-drug resistant cancer | SYNTA PHARMACEUTICALS CORP. (US) | 2010-07-27 | — | — | US | disclosed |
| US-7763658-B2 | administering bis[thio-hydrazide amide] Compounds for treating multi-drug resistant cancer | SYNTA PHARMACEUTICALS CORP. (US) | 2010-07-27 | — | — | US | disclosed |
| US-7763658-B2 | administering bis[thio-hydrazide amide] Compounds for treating multi-drug resistant cancer | SYNTA PHARMACEUTICALS CORP. (US) | 2010-07-27 | — | — | US | disclosed |
| US-7750042-B2 | Paclitaxel enhancer compound | SYNTA PHARMACEUTICALS CORP. (US) | 2010-07-06 | — | — | US | disclosed |
| US-7750042-B2 | Paclitaxel enhancer compound | SYNTA PHARMACEUTICALS CORP. (US) | 2010-07-06 | — | — | US | disclosed |
| US-7750042-B2 | Paclitaxel enhancer compound | SYNTA PHARMACEUTICALS CORP. (US) | 2010-07-06 | — | — | US | disclosed |
| US-7652168-B2 | Synthesis of taxol enhancers | SYNTA PHARMACEUTICALS CORP. (US) | 2010-01-26 | — | — | US | disclosed |
| US-7652168-B2 | Synthesis of taxol enhancers | SYNTA PHARMACEUTICALS CORP. (US) | 2010-01-26 | — | — | US | disclosed |
| US-20040229952-A1 | Synthesis of taxol enhancers | SYNTA PHARMACEUTICALS CORP. | 2004-11-18 | — | — | US | disclosed |
| US-20040225016-A1 | administering bis[thio-hydrazide amide] Compounds for treating multi-drug resistant cancer | SYNTA PHARMACEUTICALS CORPORATION | 2004-11-11 | — | — | US | disclosed |
| WO-2004064826-A1 | BIS (THIO-HYDRAZIDE AMIDE) COMPOUNDS FOR TREATING MULTI-DRUG RESISTANT CANCER | SYNTA PHARMACEUTICALS CORP. (US) | 2004-08-05 | — | — | WO | disclosed |
| US-6762204-B2 | CERTAIN BIS(THIO-HYDRAZIDE AMIDE) COMPOUNDS SIGNIFICANTLY ENHANCE THE ANTICANCER ACTIVITY OF TAXOL. | SYNTA PHARMACEUTICALS, INC. | 2004-07-13 | — | — | US | disclosed |
| EP-1406870-A1 | TAXOL ENHANCER COMPOUNDS | Synta Pharmaceuticals Corporation (US) | 2004-04-14 | — | — | EP | disclosed |
| EP-1406868-A1 | SYNTHESIS OF TAXOL ENHANCERS | Synta Pharmaceuticals Corporation (US) | 2004-04-14 | — | — | EP | disclosed |
| US-20030069225-A1 | Synthesis of taxol enhancers | SHIONOGI BIORESEARCH CORP. | 2003-04-10 | — | — | US | disclosed |
| US-20030045518-A1 | Taxol enhancer compounds | SHIONOGI BIORESEARCH CORP. (US) | 2003-03-06 | — | — | US | disclosed |
| WO-2003006428-A1 | TAXOL ENHANCER COMPOUNDS | SYNTA PHARMACEUTICALS CORP. (US) | 2003-01-23 | — | — | WO | disclosed |
| WO-2003006429-A1 | SYNTHESIS OF TAXOL ENHANCERS | SYNTA PHARMACEUTICALS CORP. (US) | 2003-01-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045518-A1 | Taxol enhancer compounds | CCNY, CENPE, CCR1 | HTT 1645/4885HPGD 3089/4885ACHE 970/4885 |
| US-20040225016-A1 | administering bis[thio-hydrazide amide] Compounds for treating multi-drug resistant cancer | CBR1, ABCC1, CBR3 | HTT 1422/4885HPGD 1433/4885ACHE 2672/4885 |
| US-20030069225-A1 | Synthesis of taxol enhancers | TOP2B, TUBB1, TUBA1B | HTT 308/4885HPGD 1306/4885ACHE 1357/4885 |
| US-20040229952-A1 | Synthesis of taxol enhancers | TOP2B, TUBB1, TUBA1B | HTT 308/4885HPGD 1306/4885ACHE 1357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.