Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 4/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.47 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8358322 | 0.74 | TSHR (0.71) | MAPK10TSHRMAPTLMNAMAPK1 | |
| SCHEMBL31531433 | 0.70 | MAPK10 (0.69) | MAPK10TSHRMAPTLMNAMAPK1 | |
| SCHEMBL8588169 | 0.69 | HTR2C (0.46) | TDP1 | |
| SCHEMBL31439456 | 0.68 | ALDH1A1 (0.53) | MAPK10TSHRLMNAMAPK1HSD17B10 | |
| SCHEMBL7933290 | 0.67 | MAPK8 (0.66) | MAPK10MAPTLMNAMAPK1MAPK8 | |
| SCHEMBL5915114 | 0.67 | HTR2C (0.44) | HTR1ATDP1 | |
| SCHEMBL5294918 | 0.66 | MAPK8 (0.68) | MAPK10MAPTLMNAMAPK1MAPK8 | |
| SCHEMBL4477277 | 0.66 | KMT2A (0.71) | MAPK10MAPTLMNAMAPK1HSD17B10 | |
| SCHEMBL1039299 | 0.66 | MAPK8 (1.00) | MAPK10LMNAMAPK8MAPK9SMN1; SMN2 | |
| SCHEMBL8358036 | 0.66 | POLB (0.72) | MAPK10TSHRMAPTLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999031096-A1 | PIPERAZINE DERIVATIVES USEFUL AS HYPOGLYCEMIC AGENTS | SHAMAN PHARMACEUTICALS, INC. (US) | 1999-06-24 | — | — | WO | claimed |