SCHEMBL8359255

SCHEMBL8359255

COc1ccc(C(=O)CC(=O)Cl)cc1

nearest known ligand 0.78

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.62
LMNA P02545 1/20 0.62
ALOX15 P16050 1/20 0.62
APEX1 P27695 1/20 0.62
MAPK1 P28482 1/20 0.62
RECQL P46063 1/20 0.62
HSD17B10 Q99714 1/20 0.62
TDP1 Q9NUW8 1/20 0.62
HDAC3 O15379 2/20 0.61
HDAC4 P56524 2/20 0.61
HDAC1 Q13547 2/20 0.61
HDAC7 Q8WUI4 2/20 0.61
HDAC2 Q92769 2/20 0.61
HDAC10 Q969S8 2/20 0.61
HDAC11 Q96DB2 2/20 0.61
HDAC8 Q9BY41 2/20 0.61
HDAC6 Q9UBN7 2/20 0.61
HDAC9 Q9UKV0 2/20 0.61
HDAC5 Q9UQL6 2/20 0.61
GSK3B P49841 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL153386 0.88 ALDH1A1 (0.76) ALDH1A1LMNAALOX15APEX1MAPK1
SCHEMBL29219054 0.84 ALDH1A1 (0.66) ALDH1A1LMNAALOX15APEX1MAPK1
SCHEMBL271455 0.83 MEN1 (0.52) ALDH1A1ALOX15MAPK1TDP1GSK3B
SCHEMBL28824890 0.83 KCNH2 (0.70) ALDH1A1LMNAALOX15APEX1MAPK1
SCHEMBL1374066 0.82 ALDH1A1 (0.64) ALDH1A1LMNAALOX15APEX1MAPK1
SCHEMBL1398724 0.82 ALDH1A1 (0.64) ALDH1A1LMNAALOX15APEX1MAPK1
SCHEMBL17295084 0.82 ALDH1A1 (0.64) ALDH1A1LMNAALOX15APEX1MAPK1
SCHEMBL2427418 0.82 PDE4B (0.66) ALDH1A1LMNAALOX15APEX1MAPK1
SCHEMBL29897882 0.81 ALDH1A1 (0.58) ALDH1A1LMNAALOX15APEX1MAPK1
SCHEMBL7631387 0.81 NPC1 (0.69) ALDH1A1LMNAALOX15APEX1MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3022180-B1 UV ABSORBING COMPOUNDS, COMPOSITIONS COMPRISING SAME AND USES THEREOF CORAL SUNSCREEN PTY LTD (AU) 2022-02-23 EP disclosed
US-20180155288-A1 UV Absorbing Compounds, Compositions Comprising Same and Uses Thereof CORAL SUNSCREEN PTY LTD (AU) 2018-06-07 US disclosed
US-20180155288-A1 UV Absorbing Compounds, Compositions Comprising Same and Uses Thereof CORAL SUNSCREEN PTY LTD (AU) 2018-06-07 US disclosed
US-9920009-B2 UV absorbing compounds, compositions comprising same and uses thereof CORAL SUNSCREEN PTY LTD (AU) 2018-03-20 US disclosed
US-20160244409-A1 UV Absorbing Compounds, Compositions Comprising Same and Uses Thereof CORAL SUNSCREEN PTY LTD (AU) 2016-08-25 US disclosed
US-20160244409-A1 UV Absorbing Compounds, Compositions Comprising Same and Uses Thereof CORAL SUNSCREEN PTY LTD (AU) 2016-08-25 US disclosed
WO-1999029640-A2 COMPOSITIONS AND METHODS FOR MODULATING THE ACTIVITY OF FIBROBLAST GROWTH FACTOR EISAI CO., LTD. (JP) 1999-06-17 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180155288-A1 UV Absorbing Compounds, Compositions Comprising Same and Uses Thereof ERCC1, ERCC4, ERCC5 ALDH1A1 662/4885LMNA 2110/4885ALOX15 2171/4885
US-20160244409-A1 UV Absorbing Compounds, Compositions Comprising Same and Uses Thereof ERCC4, ERCC1, ERCC5 ALDH1A1 538/4885LMNA 1773/4885ALOX15 1647/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.