SCHEMBL7631387

SCHEMBL7631387

COc1ccc(C(=O)CC(=O)c2ccc(C)cc2)cc1

nearest known ligand 0.85

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 6/20 0.69
RAB9A P51151 4/20 0.69
MEN1 O00255 2/20 0.69
KMT2A Q03164 2/20 0.69
LMNA P02545 2/20 0.67
ALDH1A1 P00352 1/20 0.67
ALOX15 P16050 1/20 0.67
APEX1 P27695 1/20 0.67
MAPK1 P28482 1/20 0.67
RECQL P46063 1/20 0.67
HSD17B10 Q99714 1/20 0.67
TDP1 Q9NUW8 1/20 0.67
HTT P42858 1/20 0.62
SMN1; SMN2 Q16637 1/20 0.62
NPSR1 Q6W5P4 1/20 0.62
GSK3B P49841 1/20 0.61
HDAC3 O15379 1/20 0.61
HDAC4 P56524 1/20 0.61
HDAC1 Q13547 1/20 0.61
HDAC7 Q8WUI4 1/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL153386 0.92 ALDH1A1 (0.76) NPC1KMT2ALMNAALDH1A1ALOX15
SCHEMBL13624720 0.87 NPC1 (0.57) NPC1RAB9AMEN1KMT2ALMNA
SCHEMBL600578 0.85 RAB9A (0.83) NPC1RAB9AMEN1KMT2ALMNA
SCHEMBL268888 0.85 NPC1 (0.70) NPC1RAB9AMEN1KMT2ALMNA
SCHEMBL6627891 0.85 KMT2A (0.69) NPC1RAB9AMEN1KMT2AALDH1A1
SCHEMBL13632677 0.85 ALDH1A1 (0.63) NPC1RAB9AMEN1KMT2ALMNA
SCHEMBL747850 0.85 NPC1 (0.71) NPC1RAB9AMEN1KMT2ALMNA
SCHEMBL4197234 0.85 NPC1 (0.71) NPC1RAB9AMEN1KMT2ALMNA
SCHEMBL9449257 0.85 ESR2 (0.68) NPC1RAB9AMEN1KMT2ALMNA
SCHEMBL30114928 0.85 ALOX15 (0.67) NPC1RAB9AMEN1KMT2ALMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220008298-A1 OLEOGELS IN UV ABSORBER COMPOSITIONS BASF SE (DE) 2022-01-13 US disclosed
US-11041119-B2 Europium beta-diketonate luminescent material Melman, Jonathan (US) 2021-06-22 US disclosed
US-20190161674-A1 EUROPIUM BETA-DIKETONATE LUMINESCENT MATERIAL MELMAN, JONATHAN 2019-05-30 US disclosed
US-20170290756-A1 MIXTURES OF COSMETIC UV ABSORBERS BASF SCHWEIZ AG (CH) 2017-10-12 US disclosed
US-20170290756-A1 MIXTURES OF COSMETIC UV ABSORBERS BASF SCHWEIZ AG (CH) 2017-10-12 US disclosed
US-9561993-B2 Process for the manufacture of dibenzoylmethane derivatives DSM IP ASSETS B.V. (NL) 2017-02-07 US disclosed
US-20140017183-A1 PROCESS FOR THE MANUFACTURE OF DIBENZOYLMETHANE DERIVATIVES DSM IP ASSETS B.V. (NL) 2014-01-16 US disclosed
US-8409792-B2 Color intermediate motion picture film EAST KODAK COMPANY (US) 2013-04-02 US disclosed
US-7998665-B2 Color intermediate motion picture film EASTMAN KODAK COMPANY (US) 2011-08-16 US disclosed
US-20100167218-A1 COLOR INTERMEDIATE MOTION PICTURE FILM EASTMAN KODAK COMPANY 2010-07-01 US disclosed
US-20090325108-A1 COLOR PHOTOGRAPHIC MATERIALS WITH MAGENTA MINIMUM DENSITY DYES LASER PACIFIC MEDIA CORPORATION 2009-12-31 US disclosed
US-7632632-B1 Color photographic materials with magenta minimum density dyes EASTMAN KODAK COMPANY (US) 2009-12-15 US disclosed
US-7629112-B1 Color photographic materials with yellow minimum density colorants EASTMAN KODAK COMPANY (US) 2009-12-08 US disclosed
US-20090297992-A1 COLOR PHOTOGRAPHIC MATERIALS WITH YELLOW MINIMUM DENSITY COLORANTS KODAK (NEAR EAST) INC. 2009-12-03 US disclosed
US-20090234131-A1 INFRARED DYE FOR SILVER HALIDE-BASED PHOTOGRAPHIC ELEMENTS EASTMAN KODAK COMPANY (US) 2009-09-17 US disclosed
US-7354661-B2 Electroluminescent devices OLED-T LIMITED (GB) 2008-04-08 US disclosed
US-7345090-B2 Galenical formulation MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 2008-03-18 US disclosed
US-6448304-B1 POLYURETHANE, POLYTHIOURETHANE OR DIETHYLENE GLYCOL BISALLYLCARBONATE POLYMER; DIPPING IN SOLUTION CONTAINING A DIBENZOYLMETHANE OR A BENZOTRIZOLE COMPOUND; PLASTIC LENS FOR SPECTACLES WHICH ABSORBS ULTRAVIOLET RAYS; LOW YELLOWNESS HOYA CORPORATION (JP) 2002-09-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170290756-A1 MIXTURES OF COSMETIC UV ABSORBERS C5, C9, C3AR1 NPC1 3008/4885RAB9A 4534/4885MEN1 231/4885
US-20090234131-A1 INFRARED DYE FOR SILVER HALIDE-BASED PHOTOGRAPHIC ELEMENTS IK, HTT, HYPK NPC1 1822/4885RAB9A 2873/4885MEN1 4619/4885
US-20140017183-A1 PROCESS FOR THE MANUFACTURE OF DIBENZOYLMETHANE DERIVATIVES DDT, DHPS, BCDIN3D NPC1 3550/4885RAB9A 1944/4885MEN1 1557/4885
US-20220008298-A1 OLEOGELS IN UV ABSORBER COMPOSITIONS ERCC4, SUN2, ERCC1 NPC1 332/4885RAB9A 2050/4885MEN1 3406/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.