Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 2/20 | 0.33 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NR2E1 | Q9Y466 | 2/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8362098 | 0.90 | AGTR1 (0.35) | PLA2G2AFGFR1SRCESR2AGTR1 | |
| SCHEMBL8359535 | 0.86 | FGFR1 (0.36) | FGFR1SRCESR2MEN1KMT2A | |
| SCHEMBL8359335 | 0.85 | PLA2G2A (0.36) | PLA2G2AFGFR1SRCESR2MEN1 | |
| SCHEMBL8359913 | 0.84 | FGFR1 (0.34) | FGFR1SRCESR2RIPK1ALDH1A1 | |
| SCHEMBL8362079 | 0.83 | AGTR1 (0.36) | PLA2G2AFGFR1SRCESR2AGTR1 | |
| SCHEMBL8587857 | 0.82 | FGFR1 (0.36) | FGFR1SRCESR2PDE5AALDH1A1 | |
| SCHEMBL8419025 | 0.80 | FGFR1 (0.36) | FGFR1SRCMEN1KMT2ADYRK1A | |
| SCHEMBL8587444 | 0.80 | TSHR (0.36) | PDE5AAGTR2 | |
| SCHEMBL8361981 | 0.80 | PTPN11 (0.37) | ALDH1A1 | |
| SCHEMBL8357507 | 0.79 | FGFR1 (0.34) | FGFR1SRCESR2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883111-A | STRONG AND LONG-LASTING ACTION BY ORAL ADMINISTRATION; HYPOTENSIVE AGENTS; CARDIOTONIC AGENTS; ALZHEIMER'S DISEASE; | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-03-16 | — | — | US | disclosed |
| US-5736555-A | HYPOTENSIVE AGENTS; FDA ORANGE BOOK LISTED PATENT FOR AZILSARTAN MEDOXOMIL | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-04-07 | — | — | US | disclosed |