Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 4/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.34 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8587857 | 0.91 | FGFR1 (0.36) | FGFR1SRCPDE5AESR2ESR1 | |
| SCHEMBL8357507 | 0.88 | FGFR1 (0.34) | FGFR1SRCPDE5AESR2ESR1 | |
| SCHEMBL8362079 | 0.87 | AGTR1 (0.36) | FGFR1SRCESR2ESR1DYRK1A | |
| SCHEMBL8357513 | 0.87 | TSHR (0.39) | PDE5AKDM4ELMNAAGTR2 | |
| SCHEMBL8357506 | 0.86 | FGFR1 (0.36) | FGFR1SRCPDE5AESR2ESR1 | |
| SCHEMBL8711112 | 0.86 | AGTR2 (0.44) | FGFR1SRCBTKAGTR2 | |
| SCHEMBL8361978 | 0.86 | PLA2G2A (0.36) | FGFR1SRCPDE5AESR2DYRK1A | |
| SCHEMBL8363472 | 0.85 | FGFR1 (0.34) | FGFR1SRCPDE5AESR2ESR1 | |
| SCHEMBL8421706 | 0.84 | FGFR1 (0.37) | FGFR1SRCESR2ESR1DYRK1A | |
| SCHEMBL8359335 | 0.81 | PLA2G2A (0.36) | FGFR1SRCPDE5AESR2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883111-A | STRONG AND LONG-LASTING ACTION BY ORAL ADMINISTRATION; HYPOTENSIVE AGENTS; CARDIOTONIC AGENTS; ALZHEIMER'S DISEASE; | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-03-16 | — | — | US | disclosed |
| US-5736555-A | HYPOTENSIVE AGENTS; FDA ORANGE BOOK LISTED PATENT FOR AZILSARTAN MEDOXOMIL | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-04-07 | — | — | US | disclosed |