Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 known ✓ | P25103 | 8/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | RXRA | P19793 | 1/20 | 0.31 |
| ▸ | RXRB | P28702 | 1/20 | 0.31 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.30 |
| ▸ | MEN1 | O00255 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8366096 | 0.96 | TACR1 (0.35) | TACR1RXRARXRBGPBAR1 | |
| Hydrochloric Acid SCHEMBL8364768 | 0.96 | TACR1 (0.35) | TACR1RXRARXRBGPBAR1 | |
| Hydrochloric Acid SCHEMBL8364269 | 0.86 | RXRB (0.33) | RXRARXRB | |
| Hydrochloric Acid SCHEMBL8361840 | 0.85 | TACR1 (0.33) | TACR1HTR1AHTR7RXRARXRB | |
| Hydrochloric Acid SCHEMBL8366175 | 0.82 | TACR1 (0.36) | TACR1RXRARXRBGPBAR1MEN1 | |
| Hydrochloric Acid SCHEMBL8361917 | 0.82 | TACR1 (0.36) | TACR1RXRARXRBGPBAR1MEN1 | |
| Hydrochloric Acid SCHEMBL8365950 | 0.82 | LMNA (0.32) | — | |
| SCHEMBL8366201 | 0.77 | TACR1 (0.32) | TACR1IKBKBHTR1AHTR7RXRA | |
| Hydrochloric Acid SCHEMBL6927034 | 0.77 | TACR1 (0.34) | TACR1 | |
| Hydrochloric Acid SCHEMBL7526331 | 0.75 | HTR1A (0.32) | TACR1HTR1AHTR7MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999035171-A1 | HIGH-MELTING POLYOLEFIN COPOLYMER ELASTOMERS, CATALYSTS AND METHODS OF SYNTHESIS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JR. UNIVERSITY (US) | 1999-07-15 | — | — | WO | disclosed |