Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | PPARG | P37231 | 2/20 | 0.32 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8363436 | 0.94 | AGTR1 (0.37) | PPARGAGTR1AGTR2 | |
| SCHEMBL8359678 | 0.93 | PPARG (0.39) | PPARGAGTR1AGTR2 | |
| SCHEMBL8587441 | 0.91 | AGTR2 (0.35) | PARP1PDCD1CD274PPARGAGTR1 | |
| SCHEMBL8356855 | 0.85 | AGTR1 (0.38) | PPARGAGTR1AGTR2 | |
| SCHEMBL8362097 | 0.84 | PPARG (0.39) | PPARGAGTR2 | |
| SCHEMBL8587855 | 0.81 | PPARG (0.38) | PPARG | |
| SCHEMBL8357510 | 0.81 | AGTR2 (0.37) | PDCD1CD274PPARGAGTR1AGTR2 | |
| SCHEMBL8361975 | 0.81 | ALDH1A1 (0.36) | PPARG | |
| SCHEMBL8363455 | 0.80 | PDCD1 (0.36) | PDCD1CD274SLC6A4SLC6A3 | |
| SCHEMBL8589024 | 0.80 | TP53 (0.35) | PPARGAGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883111-A | STRONG AND LONG-LASTING ACTION BY ORAL ADMINISTRATION; HYPOTENSIVE AGENTS; CARDIOTONIC AGENTS; ALZHEIMER'S DISEASE; | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-03-16 | — | — | US | disclosed |
| US-5736555-A | HYPOTENSIVE AGENTS; FDA ORANGE BOOK LISTED PATENT FOR AZILSARTAN MEDOXOMIL | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-04-07 | — | — | US | disclosed |