Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 6/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | ICMT | O60725 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8366153 | 0.85 | THRB (0.43) | THRBBRD4HTTKDM4EALDH1A1 | |
| SCHEMBL8366307 | 0.82 | ALDH1A1 (0.47) | THRBHTTALDH1A1HPGDRXFP1 | |
| SCHEMBL15565909 | 0.82 | THRB (0.42) | THRBBRD4HTTKDM4EALDH1A1 | |
| SCHEMBL8367148 | 0.81 | AKR1C3 (0.49) | THRBBRD4HTTKDM4EALDH1A1 | |
| SCHEMBL9153374 | 0.80 | KDM4E (0.56) | BRD4HTTKDM4EALDH1A1HPGD | |
| SCHEMBL8366314 | 0.79 | BRD1 (0.42) | BRD4HSD17B10 | |
| SCHEMBL8366324 | 0.78 | THRB (0.47) | THRBBRD4HTTKDM4EALDH1A1 | |
| SCHEMBL21614279 | 0.77 | KDM4E (0.50) | KDM4EALDH1A1MEN1KMT2ARXFP1 | |
| SCHEMBL31563337 | 0.77 | KDM4E (0.41) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL13440436 | 0.76 | KDM4E (0.50) | THRBBRD4KDM4EALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850235-B1 | QUINOLEIN-2(1H)-ONE DERIVATIVES AS SEROTONIN ANTAGONISTS | SANOFI SYNTHELABO (FR) | 1999-12-01 | — | — | EP | disclosed |
| US-5958924-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS, RESTENOSIS, ANTICOALUGANTS, RESPIRATORY SYSTEM DISORDERS | SYNTHELABO (FR) | 1999-09-28 | — | — | US | disclosed |