Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 3/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.46 |
| ▸ | PTGDR | Q13258 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ICMT | O60725 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1775541 | 0.89 | ATM (0.46) | AKR1C3AKR1C2KDM4EALDH1A1HPGD | |
| SCHEMBL8366324 | 0.85 | THRB (0.47) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL9766045 | 0.84 | MEN1 (0.51) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL8457832 | 0.83 | KDM4E (0.48) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL8364439 | 0.83 | ALDH1A1 (0.49) | AKR1C3AKR1C2KDM4EALDH1A1HPGD | |
| SCHEMBL8364438 | 0.81 | THRB (0.43) | KDM4EALDH1A1HPGDHSD17B10THRB | |
| SCHEMBL9157244 | 0.81 | KDM4E (0.56) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL15565909 | 0.81 | THRB (0.42) | KDM4EALDH1A1HPGDTHRBBRD4 | |
| SCHEMBL8366206 | 0.81 | KDM4E (0.55) | AKR1C3AKR1C2KDM4EALDH1A1HPGD | |
| SCHEMBL9156302 | 0.81 | KDM4E (0.46) | KDM4EALDH1A1HPGDHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1094490-C | Quinolin-2 (1H) -one derivatives as serotonin antagonists | SANOFI SYNTHELABO (FR) | 2002-11-20 | — | — | CN | disclosed |
| EP-0850235-B1 | QUINOLEIN-2(1H)-ONE DERIVATIVES AS SEROTONIN ANTAGONISTS | SANOFI SYNTHELABO (FR) | 1999-12-01 | — | — | EP | disclosed |
| US-5958924-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS, RESTENOSIS, ANTICOALUGANTS, RESPIRATORY SYSTEM DISORDERS | SYNTHELABO (FR) | 1999-09-28 | — | — | US | disclosed |
| CN-1202168-A | Quinolein-2(1H)-one derivatives as serotonin antagonists | SYNTHELABO (FR) | 1998-12-16 | — | — | CN | disclosed |