Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8362030 | 0.90 | PDCD1 (0.39) | PDCD1CD274AGTR1SLC6A3SLC6A4 | |
| SCHEMBL8532947 | 0.83 | PDCD1 (0.36) | PDCD1CD274AGTR1POLBSLC6A3 | |
| SCHEMBL8362109 | 0.80 | PPARG (0.43) | AGTR1AGTR2 | |
| SCHEMBL8359346 | 0.79 | AGTR1 (0.40) | AGTR1AGTR2 | |
| SCHEMBL8357510 | 0.78 | AGTR2 (0.37) | PDCD1CD274AGTR1POLBLMNA | |
| SCHEMBL7019189 | 0.78 | AGTR2 (0.57) | AGTR1SLC6A3LTB4R2SLC6A2AGTR2 | |
| SCHEMBL8417421 | 0.77 | AGTR1 (0.34) | PDCD1CD274AGTR1LTB4R2SLC6A2 | |
| SCHEMBL8587441 | 0.77 | AGTR2 (0.35) | PDCD1CD274AGTR1POLBSLC6A3 | |
| SCHEMBL8357459 | 0.77 | AGTR2 (0.36) | PDCD1CD274POLBLMNAAGTR2 | |
| SCHEMBL8536331 | 0.76 | AGTR1 (0.42) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5883111-A | STRONG AND LONG-LASTING ACTION BY ORAL ADMINISTRATION; HYPOTENSIVE AGENTS; CARDIOTONIC AGENTS; ALZHEIMER'S DISEASE; | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-03-16 | — | — | US | disclosed |
| US-5736555-A | HYPOTENSIVE AGENTS; FDA ORANGE BOOK LISTED PATENT FOR AZILSARTAN MEDOXOMIL | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-04-07 | — | — | US | disclosed |