SCHEMBL8366016

SCHEMBL8366016

C=CCOc1ccc(OC(=O)C2CCC(OC)CC2)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.46
HTT P42858 1/20 0.46
KMT2A Q03164 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
NPC1 O15118 3/20 0.44
MAPT P10636 3/20 0.44
RAB9A P51151 2/20 0.44
ELANE P08246 2/20 0.43
POLB P06746 3/20 0.42
GAA P10253 1/20 0.40
HPGD P15428 1/20 0.40
MTNR1A P48039 1/20 0.39
CA12 O43570 1/20 0.38
CA1 P00915 1/20 0.38
CA2 P00918 1/20 0.38
CA7 P43166 1/20 0.38
CA9 Q16790 1/20 0.38
F2 P00734 1/20 0.38
USP2 O75604 2/20 0.37
TSHR P16473 2/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9617786 0.84 SMN1; SMN2 (0.46) SMN1; SMN2HTTKMT2ATDP1NPC1
SCHEMBL9617785 0.84 SMN1; SMN2 (0.46) SMN1; SMN2HTTKMT2ATDP1NPC1
SCHEMBL10000345 0.83 KMT2A (0.42) SMN1; SMN2HTTKMT2ATDP1ELANE
SCHEMBL22543451 0.82 HTT (0.50) SMN1; SMN2HTTKMT2ATDP1NPC1
SCHEMBL8366013 0.82 POLB (0.44) SMN1; SMN2KMT2ANPC1RAB9APOLB
SCHEMBL7775226 0.80 ELANE (0.51) SMN1; SMN2HTTKMT2ATDP1NPC1
SCHEMBL9458101 0.79 SMN1; SMN2 (0.41) SMN1; SMN2HTTKMT2ATDP1NPC1
SCHEMBL9458110 0.79 SMN1; SMN2 (0.41) SMN1; SMN2HTTKMT2ATDP1NPC1
SCHEMBL21400173 0.79 HTT (0.53) SMN1; SMN2HTTKMT2ATDP1ELANE
SCHEMBL24293827 0.79 HTT (0.56) SMN1; SMN2HTTKMT2ATDP1ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1047003-C Retardation layer having thin glass substrates AKZO NOLBEL N V (NL) 1999-12-01 CN disclosed
EP-0721602-B1 RETARDATION LAYER HAVING A DISPERSION ADAPTED TO THE ACTIVE LIQUID-CRYSTALLINE CELL AKZO NOBEL NV (NL) 1999-10-27 EP disclosed
US-5760859-A Retardation layer having a dispersion adapted to the active liquid-crystalline cell AKZO NOBEL NV (NL) 1998-06-02 US disclosed
CN-1132557-A Retardation layer having thin glass substrates AKZO NOBEL NV (NL) 1996-10-02 CN disclosed
EP-0721602-A1 RETARDATION LAYER HAVING A DISPERSION ADAPTED TO THE ACTIVE LIQUID-CRYSTALLINE CELL Akzo Nobel N.V. (NL) 1996-07-17 EP disclosed
WO-1995009379-A1 RETARDATION LAYER HAVING A DISPERSION ADAPTED TO THE ACTIVE LIQUID-CRYSTALLINE CELL AKZO NOBEL N.V. (NL) 1995-04-06 WO disclosed