Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD1 | O95696 | 6/20 | 0.42 |
| ▸ | BRPF1 | P55201 | 6/20 | 0.42 |
| ▸ | BRD4 | O60885 | 3/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 4/20 | 0.37 |
| ▸ | BRPF3 | Q9ULD4 | 3/20 | 0.36 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | BCL6 | P41182 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | NQO2 | P16083 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8366314 | 0.86 | BRD1 (0.42) | BRD1BRPF1BRD4HTR6CASP3 | |
| SCHEMBL8366369 | 0.80 | ALDH1A1 (0.44) | BRD1BRPF1BRD4HTR6CASP3 | |
| SCHEMBL8367875 | 0.77 | BRD4 (0.45) | BRD1BRPF1BRD4EGFRSRC | |
| SCHEMBL9159464 | 0.77 | KDM4E (0.56) | BRPF1BRD4BRD9MAPTKDM4E | |
| SCHEMBL26090101 | 0.77 | BRPF1 (0.63) | BRD1BRPF1BRD4CASP3EGFR | |
| SCHEMBL30379731 | 0.77 | BRPF1 (0.63) | BRD1BRPF1BRD4CASP3EGFR | |
| SCHEMBL23609754 | 0.76 | KDM4E (0.47) | BRD1BRPF1BRD4CASP3EGFR | |
| SCHEMBL21830597 | 0.76 | BRD1 (0.46) | BRD1BRPF1BRD4CASP3EGFR | |
| SCHEMBL29858321 | 0.72 | EGFR (0.46) | BRD1BRPF1CASP3EGFRSRC | |
| SCHEMBL6363289 | 0.72 | EGFR (0.46) | BRD1BRPF1CASP3EGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850235-B1 | QUINOLEIN-2(1H)-ONE DERIVATIVES AS SEROTONIN ANTAGONISTS | SANOFI SYNTHELABO (FR) | 1999-12-01 | — | — | EP | disclosed |
| US-5958924-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS, RESTENOSIS, ANTICOALUGANTS, RESPIRATORY SYSTEM DISORDERS | SYNTHELABO (FR) | 1999-09-28 | — | — | US | disclosed |
| EP-0850235-A1 | QUINOLEIN-2(1H)-ONE DERIVATIVES AS SEROTONIN ANTAGONISTS | SYNTHELABO (FR) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997010238-A1 | QUINOLEIN-2(1H)-ONE DERIVATIVES AS SEROTONIN ANTAGONISTS | SYNTHELABO (FR) | 1997-03-20 | — | — | WO | disclosed |