Sugi Predict

Sugi Predict / Compounds / SCHEMBL23609754

SCHEMBL23609754

SCHEMBL23609754

Cn1c(=O)cc(O)c2cc(C#N)ccc21

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ KDM4E B2RXH2 2/20 0.47
▸ MAPT P10636 2/20 0.47
▸ HSD17B10 Q99714 2/20 0.47
▸ ALDH1A1 P00352 1/20 0.47
▸ THRB P10828 1/20 0.47
▸ HPGD P15428 1/20 0.47
▸ NPSR1 Q6W5P4 1/20 0.47
▸ BRD1 O95696 6/20 0.46
▸ BRPF1 P55201 6/20 0.46
▸ EGFR P00533 1/20 0.43
▸ SRC P12931 1/20 0.43
▸ CASP3 P42574 1/20 0.42
▸ BRPF3 Q9ULD4 3/20 0.40
▸ BRD4 O60885 3/20 0.40
▸ BRD9 Q9H8M2 2/20 0.40
▸ NQO2 P16083 1/20 0.39
▸ G6PD P11413 1/20 0.38
▸ KMO O15229 1/20 0.37
▸ TDP2 O95551 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30379731 0.83 BRPF1 (0.63) KDM4EALDH1A1HPGDBRD1BRPF1
SCHEMBL26090101 0.83 BRPF1 (0.63) KDM4EALDH1A1HPGDBRD1BRPF1
SCHEMBL21830597 0.81 BRD1 (0.46) KDM4EMAPTBRD1BRPF1EGFR
SCHEMBL8366314 0.79 BRD1 (0.42) MAPTHSD17B10BRD1BRPF1EGFR
SCHEMBL8366369 0.77 ALDH1A1 (0.44) KDM4EMAPTHSD17B10ALDH1A1HPGD
SCHEMBL6363289 0.77 EGFR (0.46) KDM4EMAPTHSD17B10ALDH1A1HPGD
SCHEMBL29858321 0.77 EGFR (0.46) KDM4EMAPTHSD17B10ALDH1A1HPGD
SCHEMBL2266978 0.77 KDM4E (0.51) KDM4EMAPTHSD17B10ALDH1A1THRB
SCHEMBL8366274 0.76 BRD1 (0.42) KDM4EMAPTBRD1BRPF1EGFR
SCHEMBL20680340 0.76 KDM4E (0.50) KDM4EMAPTHSD17B10ALDH1A1THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115103841-B Substituted quinolinone piperazine compounds useful as T cell activators 百时美施贵宝公司 2024-12-27 — — CN disclosed
EP-4081513-B1 SUBSTITUTED QUINOLINONYL PIPERAZINE COMPOUNDS USEFUL AS T CELL ACTIVATORS BRISTOL MYERS SQUIBB CO (US) 2024-11-20 — — EP disclosed
US-20230061608-A1 SUBSTITUTED QUINOLINONYL PIPERAZINE COMPOUNDS USEFUL AS T CELL ACTIVATORS BRISTOL MYERS SQUIBB CO (US) 2023-03-02 — — US disclosed
US-20230061608-A1 SUBSTITUTED QUINOLINONYL PIPERAZINE COMPOUNDS USEFUL AS T CELL ACTIVATORS BRISTOL MYERS SQUIBB CO (US) 2023-03-02 — — US disclosed
CN-115103841-A Substituted quinolinonyl piperazine compounds useful as T cell activators 百时美施贵宝公司 2022-09-23 — — CN disclosed
WO-2021133748-A1 SUBSTITUTED QUINOLINONYL PIPERAZINE COMPOUNDS USEFUL AS T CELL ACTIVATORS BRISTOL-MYERS SQUIBB COMPANY (US) 2021-07-01 — — WO disclosed
WO-2021133748-A1 SUBSTITUTED QUINOLINONYL PIPERAZINE COMPOUNDS USEFUL AS T CELL ACTIVATORS BRISTOL-MYERS SQUIBB COMPANY (US) 2021-07-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230061608-A1 SUBSTITUTED QUINOLINONYL PIPERAZINE COMPOUNDS USEFUL AS T CELL ACTIVATORS DGKZ, DGKA, DGKG KDM4E 2059/4885MAPT 4515/4885HSD17B10 4185/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.