Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.80 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | MEN1 | O00255 | 4/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.51 |
| ▸ | FNTA | P49354 | 1/20 | 0.51 |
| ▸ | FNTB | P49356 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30419025 | 0.89 | PKM (1.00) | PKMSMN1; SMN2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL361312 | 0.89 | PKM (1.00) | PKMSMN1; SMN2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL8978266 | 0.85 | SMN1; SMN2 (0.81) | PKMSMN1; SMN2CYP1A2CYP3A4CYP2C19 | |
| Indole-3-Acetic Acid SCHEMBL7048296 | 0.84 | PKM (0.89) | PKMSMN1; SMN2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL9967917 | 0.81 | PKM (0.66) | PKMSMN1; SMN2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL30354024 | 0.81 | PKM (0.66) | PKMSMN1; SMN2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL29407882 | 0.81 | MAPT (0.72) | PKMSMN1; SMN2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL21479833 | 0.81 | MAPT (0.72) | PKMSMN1; SMN2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL3845771 | 0.81 | PKM (0.74) | PKMSMN1; SMN2CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL392573 | 0.81 | SMN1; SMN2 (0.85) | PKMSMN1; SMN2CYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4299987-A | — | — | None | — | — | JP | disclosed |
| US-5929067-A | N-ACYLATING AMINE DERIVATIVE OF CAPROLACTAM COMPOUND WITH A CARBOXYLIC ACID OR DERIVATIVES TO FORM AMIDE DERIVATIVE OF CAPROLACTAM COMPOUND | NOVARTIS AG (CH) | 1999-07-27 | — | — | US | disclosed |
| EP-0810991-B1 | 1-ARYL-2-ACYLAMINO-ETHANE COMPOUNDS AND THEIR USE AS NEUROKININ ESPECIALLY NEUROKININ 1 ANTAGONISTS | NOVARTIS AG (CH) | 1999-04-14 | — | — | EP | disclosed |
| EP-0810991-A1 | 1-ARYL-2-ACYLAMINO-ETHANE COMPOUNDS AND THEIR USE AS NEUROKININ ESPECIALLY NEUROKININ 1 ANTAGONISTS | Novartis AG (CH) | 1997-12-10 | — | — | EP | disclosed |
| WO-1996026183-A1 | 1-ARYL-2-ACYLAMINO-ETHANE COMPOUNDS AND THEIR USE AS NEUROKININ ESPECIALLY NEUROKININ 1 ANTAGONISTS | NOVARTIS AG (CH) | 1996-08-29 | — | — | WO | disclosed |
| US-5484940-A | ULTRAVIOLET RADIATION ABSORBERS FOR PLASTICS, AMYLOID PEPTIDE INHIBITORS, ALZHEIMER*S DISEASE | ATHENA NEUROSCIENCES, INC. | 1996-01-16 | — | — | US | disclosed |
| JP-H04299987-A | PRODUCTION OF OPTICALLY ACTIVE INDOLE HYDROXY ACIDS | KAWAKEN FINE CHEM CO LTD | 1992-10-23 | — | — | JP | disclosed |