Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.66 |
| ▸ | ATM | Q13315 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.58 |
| ▸ | DRD2 | P14416 | 1/20 | 0.58 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.57 |
| ▸ | CHRM2 | P08172 | 4/20 | 0.56 |
| ▸ | CHRM5 | P08912 | 4/20 | 0.56 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | NOS2 | P35228 | 3/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | NOS3 | P29474 | 2/20 | 0.50 |
| ▸ | NOS1 | P29475 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL655085 | 0.90 | THRB (0.58) | THRBATML3MBTL1CHRM1DRD2 | |
| SCHEMBL655086 | 0.90 | THRB (0.58) | THRBATML3MBTL1CHRM1DRD2 | |
| SCHEMBL13123493 | 0.86 | THRB (0.62) | THRBATML3MBTL1CHRM1DRD2 | |
| SCHEMBL1487940 | 0.84 | THRB (0.68) | THRBATML3MBTL1CHRM1GAA | |
| SCHEMBL1487944 | 0.84 | THRB (0.68) | THRBATML3MBTL1CHRM1GAA | |
| SCHEMBL9774826 | 0.83 | THRB (0.59) | THRBATML3MBTL1CHRM1DRD2 | |
| SCHEMBL6390964 | 0.82 | THRB (0.57) | THRBATML3MBTL1CHRM1DRD2 | |
| SCHEMBL11499799 | 0.82 | THRB (0.57) | THRBATML3MBTL1CHRM1DRD2 | |
| SCHEMBL14476235 | 0.82 | THRB (0.66) | THRBATML3MBTL1GAAKDM4E | |
| SCHEMBL1128414 | 0.82 | THRB (0.66) | THRBATML3MBTL1CHRM1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7951592-B2 | Compositions and methods for inducing cell dedifferentiation | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-05-31 | — | — | US | disclosed |
| US-7655649-B2 | Cancer; N,N-dimethyl-5-phenyl-6-(4-{[4-(5-pyridin-2-yl-1H-pyrazol-3-yl)piperidin-1-yl]methyl}phenyl) pyridazin-3-amine;; serine/threonine kinase (Akt) suppression; increased cellular potency or solubility, enhanced pharmacokinetic properties | MERCK SHARP & DOHME CORP. (US) | 2010-02-02 | — | — | US | disclosed |
| US-7592177-B2 | 2-(4-morpholinoanilino)-6-cyclohexylamino-purine; contacting a lineage committed cell (myoblast) with cell dedifferentiates into a multipotent stem cell; for repair of damaged tissues; cardiovascular, neurodegenerative disease and aging; small molecules | THE SCRIPPS RESEARCH INSTITUTE (US) | 2009-09-22 | — | — | US | disclosed |
| US-20090082369-A1 | Pyrrolo[2,3d]pyrimidine compositions and their use | OSI PHARMACEUTICALS, INC. | 2009-03-26 | — | — | US | disclosed |
| US-7504407-B2 | Compounds specific to adenosine A1 and A3 receptors and uses thereof | OSI PHARMACEUTICALS, INC. (US) | 2009-03-17 | — | — | US | disclosed |
| US-7504391-B2 | Selective D1/D5 receptor antagonists for the treatment of obesity and CNS disorders | SCHERING CORPORATION (US) | 2009-03-17 | — | — | US | disclosed |
| US-20080280889-A1 | Inhibitors of Akt Activity | MERCK SHARP & DOHME CORP. | 2008-11-13 | — | — | US | disclosed |
| US-20080070936-A1 | Compounds specific to adenosine A1 receptors and uses thereof | OSI PHARMACEUTICALS, INC. | 2008-03-20 | — | — | US | disclosed |
| US-20070254884-A1 | Compositions and Methods for Inducing Cell Dedifferentiation | THE SCRIPPS RESEARCH INSTITUTE | 2007-11-01 | — | — | US | disclosed |
| US-7160890-B2 | Compounds specific to adenosine A3 receptor and uses thereof | OSI PHARMACEUTICALS, INC. (US) | 2007-01-09 | — | — | US | disclosed |
| US-6680324-B2 | 4-AMINO-6-PHENYL-PYRROLO(2,3-D)PYRIMIDINE DERIVATIVES | OSI PHARMACEUTICALS, INC. | 2004-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070254884-A1 | Compositions and Methods for Inducing Cell Dedifferentiation | PAX3, PAX2, ALPG | THRB 1932/4885ATM 2966/4885L3MBTL1 936/4885 |
| US-20090082369-A1 | Pyrrolo[2,3d]pyrimidine compositions and their use | ADORA3, ADORA2A, ADORA1 | THRB 1072/4885ATM 2513/4885L3MBTL1 2250/4885 |
| US-20080070936-A1 | Compounds specific to adenosine A1 receptors and uses thereof | ADORA1, ADORA2A, ADORA3 | THRB 779/4885ATM 3674/4885L3MBTL1 2353/4885 |
| US-20080280889-A1 | Inhibitors of Akt Activity | AKT2, PIK3CA, AKT1 | THRB 2673/4885ATM 150/4885L3MBTL1 2944/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.