Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 5/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | BCHE | P06276 | 1/20 | 0.60 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.60 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.60 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.60 |
| ▸ | RELA | Q04206 | 1/20 | 0.60 |
| ▸ | THRB | P10828 | 1/20 | 0.59 |
| ▸ | ATM | Q13315 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | F3 | P13726 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | MAOB | P27338 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.56 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.56 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL836743 | 1.00 | TRPM8 (0.76) | TRPM8LMNABCHECYP3A4NFKB1 | |
| SCHEMBL10270950 | 0.87 | TRPM8 (1.00) | TRPM8LMNABCHECYP3A4NFKB1 | |
| SCHEMBL30532218 | 0.87 | TRPM8 (1.00) | TRPM8LMNABCHECYP3A4NFKB1 | |
| SCHEMBL18536887 | 0.85 | TRPM8 (0.76) | TRPM8LMNABCHECYP3A4NFKB1 | |
| SCHEMBL836333 | 0.84 | TRPM8 (0.70) | TRPM8LMNABCHEF3MAPT | |
| SCHEMBL836332 | 0.84 | TRPM8 (0.70) | TRPM8LMNABCHEF3MAPT | |
| SCHEMBL10270951 | 0.82 | TRPM8 (1.00) | TRPM8LMNABCHECYP3A4NFKB1 | |
| SCHEMBL18536909 | 0.82 | TRPM8 (0.83) | TRPM8LMNABCHECYP3A4NFKB1 | |
| SCHEMBL10270945 | 0.81 | TRPM8 (1.00) | TRPM8LMNABCHECYP3A4NFKB1 | |
| SCHEMBL18537071 | 0.80 | TRPM8 (0.88) | TRPM8LMNABCHECYP3A4NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143423-B2 | N-heterocyclic carbene (NHC) catalyzed synthesis of hydroxamic acids | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2012-03-27 | — | — | US | disclosed |
| US-8143423-B2 | N-heterocyclic carbene (NHC) catalyzed synthesis of hydroxamic acids | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2012-03-27 | — | — | US | disclosed |
| US-8143423-B2 | N-heterocyclic carbene (NHC) catalyzed synthesis of hydroxamic acids | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2012-03-27 | — | — | US | disclosed |
| US-20100105921-A1 | N-HETEROCYCLIC CARBENE (NHC) CATALYZED SYNTHESIS OF HYDROXAMIC ACIDS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2010-04-29 | — | — | US | disclosed |
| US-20100105921-A1 | N-HETEROCYCLIC CARBENE (NHC) CATALYZED SYNTHESIS OF HYDROXAMIC ACIDS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2010-04-29 | — | — | US | disclosed |
| US-20100105921-A1 | N-HETEROCYCLIC CARBENE (NHC) CATALYZED SYNTHESIS OF HYDROXAMIC ACIDS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2010-04-29 | — | — | US | disclosed |
| WO-2008115153-A1 | N-HETEROCYCLIC CARBENE (NHC) CATALYZED SYNTHESIS OF HYDROXAMIC ACIDS | AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (SG) | 2008-09-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100105921-A1 | N-HETEROCYCLIC CARBENE (NHC) CATALYZED SYNTHESIS OF HYDROXAMIC ACIDS | NDC1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HAO2 | TRPM8 4490/4885LMNA 802/4885BCHE 2228/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.