Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 4/20 | 0.42 |
| ▸ | SRD5A1 | P18405 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.40 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2232699 | 0.93 | ALDH1A1 (0.56) | ALDH1A1TDP1SRD5A2SRD5A1KDM4E | |
| SCHEMBL29559031 | 0.93 | ALDH1A1 (0.56) | ALDH1A1TDP1SRD5A2SRD5A1KDM4E | |
| SCHEMBL19718187 | 0.86 | ALDH1A1 (0.53) | ALDH1A1TDP1SRD5A2SRD5A1KDM4E | |
| SCHEMBL345292 | 0.81 | DRD3 (0.57) | MAPTMEN1KMT2ACYP4F2CYP4A11 | |
| SCHEMBL345291 | 0.81 | DRD3 (0.57) | MAPTMEN1KMT2ACYP4F2CYP4A11 | |
| SCHEMBL1107094 | 0.81 | NPC1 (0.49) | ALDH1A1MAPTPOLB | |
| SCHEMBL7275357 | 0.81 | ALDH1A1 (0.53) | ALDH1A1TDP1SRD5A2SRD5A1KDM4E | |
| SCHEMBL24440190 | 0.80 | HDAC8 (0.42) | ALDH1A1MAPK1HDAC8CYP4F2CYP4A11 | |
| SCHEMBL31262473 | 0.80 | HDAC8 (0.42) | ALDH1A1MAPK1HDAC8CYP4F2CYP4A11 | |
| SCHEMBL459393 | 0.80 | DRD2 (0.60) | ALDH1A1KDM4EMAPTKDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999061506-A1 | THERMOSETTING COATING COMPOSITIONS BASED ON POLYESTERS | EASTMAN CHEMICAL COMPANY (US) | 1999-12-02 | — | — | WO | claimed |
| US-9637453-B2 | 3-spirocyclic-6-hydroxamic acid tetralins as HDAC inhibitors | FORMA THERAPEUTICS, INC. (US) | 2017-05-02 | — | — | US | disclosed |
| WO-2016168598-A1 | 3-SPIROCYCLIC-6-HYDROXAMIC ACID TETRALINS AS HDAC INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2016-10-20 | — | — | WO | disclosed |
| US-20160304456-A1 | 3-SPIROCYCLIC-6-HYDROXAMIC ACID TETRALINS AS HDAC INHIBITORS | VALO HEALTH, INC. | 2016-10-20 | — | — | US | disclosed |
| US-20140031481-A1 | Polyamide compositions and article manufactured therefrom | SOLVAY SPECIALITY POLYMERS USA, LLC (US) | 2014-01-30 | — | — | US | disclosed |
| US-20140031481-A1 | Polyamide compositions and article manufactured therefrom | SOLVAY SPECIALITY POLYMERS USA, LLC (US) | 2014-01-30 | — | — | US | disclosed |
| WO-2012136693-A1 | POLYAMIDE COMPOSITION AND ARTICLE MANUFACTURED THEREFROM | SOLVAY SPECIALTY POLYMERS USA, LLC (US) | 2012-10-11 | — | — | WO | disclosed |
| WO-1999061506-A1 | THERMOSETTING COATING COMPOSITIONS BASED ON POLYESTERS | EASTMAN CHEMICAL COMPANY (US) | 1999-12-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160304456-A1 | 3-SPIROCYCLIC-6-HYDROXAMIC ACID TETRALINS AS HDAC INHIBITORS | HDAC1, HDAC11, HDAC6 | ALDH1A1 317/4885TDP1 1283/4885SRD5A2 1253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.