Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.35 |
| ▸ | PTPRB | P23467 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.33 |
| ▸ | SCN4A | P35499 | 2/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL836674 | 0.81 | KMT2A (0.41) | KMT2AMEN1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL14997055 | 0.81 | MAPT (0.47) | KMT2AMEN1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL3190087 | 0.78 | MEN1 (0.59) | KMT2AMEN1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL836544 | 0.75 | MAPT (0.40) | KMT2AMEN1ALDH1A1POLBHPGD | |
| SCHEMBL12936082 | 0.75 | HTR2A (0.43) | ALDH1A1HPGDHSD17B10KDM4EMAPT | |
| SCHEMBL4687492 | 0.74 | HTR1A (0.42) | KMT2AMEN1ALDH1A1HSD17B10KDM4E | |
| SCHEMBL10097969 | 0.74 | MEN1 (0.38) | KMT2AMEN1ALDH1A1POLBHPGD | |
| SCHEMBL836680 | 0.74 | ALDH1A1 (0.40) | KMT2AMEN1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL836542 | 0.73 | KMT2A (0.56) | KMT2AMEN1ALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL4685426 | 0.73 | S1PR1 (0.39) | KMT2AMEN1ALDH1A1KDM4ECYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143421-B2 | Broadspectrum substituted benzimidazole sulfonamide HIV protease inhibitors | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2012-03-27 | — | — | US | disclosed |
| US-8143421-B2 | Broadspectrum substituted benzimidazole sulfonamide HIV protease inhibitors | TIBOTEC PHARMACEUTICALS LTD. (IE) | 2012-03-27 | — | — | US | disclosed |
| US-20090203743-A1 | SMALL MOLECULE ENTRY INHIBITORS | SURLERAUX DOMINIQUE LOUIS | 2009-08-13 | — | — | US | disclosed |
| US-20090203743-A1 | SMALL MOLECULE ENTRY INHIBITORS | SURLERAUX DOMINIQUE LOUIS | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203743-A1 | SMALL MOLECULE ENTRY INHIBITORS | NR0B1, LTC4S, LTB4R | KMT2A 3153/4885MEN1 1185/4885ALDH1A1 1880/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.