Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 2/20 | 0.57 |
| ▸ | IDO1 | P14902 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8367237 | 0.87 | MAPT (0.55) | CDK4IDO1MAPTLMNAMAPK1 | |
| SCHEMBL8368915 | 0.84 | CDK4 (0.65) | CDK4IDO1MAPTLMNAMAPK1 | |
| SCHEMBL8368813 | 0.83 | CDK4 (0.53) | CDK4IDO1MAPTLMNAMAPK1 | |
| SCHEMBL8369508 | 0.78 | CDK4 (0.60) | CDK4IDO1MAPTLMNAMAPK1 | |
| SCHEMBL8371662 | 0.76 | CDK4 (0.50) | CDK4IDO1MAPTALDH1A1TDP1 | |
| SCHEMBL8367064 | 0.76 | CDK4 (0.62) | CDK4IDO1MAPTLMNAMAPK1 | |
| SCHEMBL16296903 | 0.74 | MAPT (0.69) | CDK4IDO1MAPTLMNAMAPK1 | |
| SCHEMBL29633276 | 0.74 | MAPT (0.69) | CDK4IDO1MAPTLMNAMAPK1 | |
| SCHEMBL10506975 | 0.73 | ALDH1A1 (0.71) | CDK4IDO1MAPTLMNAMAPK1 | |
| SCHEMBL19409875 | 0.73 | MAPT (0.61) | CDK4IDO1MAPTLMNAMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999052365-A1 | ANTICANCER AGENTS | ELI LILLY AND COMPANY (US) | 1999-10-21 | — | — | WO | disclosed |