SCHEMBL8370673

SCHEMBL8370673

CCC1=Cc2c(C)cccc2C1[Si](C)(C)C1C(CC)=Cc2c(C)cccc21

nearest known ligand 0.31

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 1/20 0.31
HTR2C P28335 1/20 0.31
HTR2B P41595 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1451567 0.82
SCHEMBL7034550 0.79 SYK (0.33)
SCHEMBL1454519 0.79 HTR2C (0.31) HTR2AHTR2CHTR2B
SCHEMBL5836913 0.78 ADRB2 (0.33) HTR2B
SCHEMBL7038530 0.76 EDNRB (0.35)
SCHEMBL28890907 0.76 MEN1 (0.31)
Hydrochloric Acid SCHEMBL5168251 0.76
SCHEMBL7593800 0.76 MEN1 (0.34)
SCHEMBL5836023 0.75 ALOX15 (0.35)
Hydrochloric Acid SCHEMBL28411922 0.75 MEN1 (0.30)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0617044-B1 Process for preparing cyclopentadienyl group-containing silicon compound or cyclopentadienyl group-containing germanium compound MITSUI CHEMICALS INC (JP) 1999-01-20 EP disclosed
US-5360921-A REACTING LITHIUM, SODIUM OR POTASSIUM SALT OF A CYCLOPENTADIENE DERIVATIVE WITH A SILICON OR GERMANIUM HALIDE COMPOUND IN THE PRESENCE OF A CYANIDE OR A THIOCYANATE MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1994-11-01 US disclosed
EP-0617044-A2 Process for preparing cyclopentadienyl group-containing silicon compound or cyclopentadienyl group-containing germanium compound MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1994-09-28 EP disclosed