SCHEMBL8370739

SCHEMBL8370739

CC1=Cc2ccccc2C1C([SiH3])C1C(C)=Cc2ccccc21

nearest known ligand 0.32

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 1/20 0.32
DRD2 P14416 1/20 0.32
DRD4 P21917 1/20 0.32
ALDH1A1 P00352 1/20 0.30
LMNA P02545 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6266174 0.81 HTR2A (0.34) TACR1ALDH1A1LMNA
SCHEMBL27774613 0.81 HTR2A (0.34) TACR1ALDH1A1LMNA
SCHEMBL12814519 0.76 LMNA (0.37) TACR1LMNA
SCHEMBL8861792 0.75 GPR3 (0.31) TACR1
SCHEMBL19816957 0.75 HTR2A (0.31) TACR1
SCHEMBL6905138 0.74 LMNA (0.32) DRD2DRD4ALDH1A1LMNA
SCHEMBL16458893 0.73 TACR1 (0.40) TACR1LMNA
SCHEMBL9059717 0.73 LMNA (0.30) LMNA
SCHEMBL8149969 0.73 LMNA (0.35) DRD2DRD4ALDH1A1LMNA
SCHEMBL27602854 0.72 LMNA (0.31) LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0617044-B1 Process for preparing cyclopentadienyl group-containing silicon compound or cyclopentadienyl group-containing germanium compound MITSUI CHEMICALS INC (JP) 1999-01-20 EP disclosed
US-5360921-A REACTING LITHIUM, SODIUM OR POTASSIUM SALT OF A CYCLOPENTADIENE DERIVATIVE WITH A SILICON OR GERMANIUM HALIDE COMPOUND IN THE PRESENCE OF A CYANIDE OR A THIOCYANATE MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1994-11-01 US disclosed
EP-0617044-A2 Process for preparing cyclopentadienyl group-containing silicon compound or cyclopentadienyl group-containing germanium compound MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1994-09-28 EP disclosed