SCHEMBL8370769

SCHEMBL8370769

Brc1cc2nc[nH]c2cc1Br

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.56
ALDH1A1 P00352 2/20 0.56
KDM4E B2RXH2 2/20 0.56
TDP1 Q9NUW8 2/20 0.56
APEX1 P27695 1/20 0.56
RECQL P46063 1/20 0.56
BLM P54132 1/20 0.56
PRKCI P41743 1/20 0.47
KMT2A Q03164 2/20 0.46
MEN1 O00255 1/20 0.46
PRNP P04156 1/20 0.46
HPGD P15428 1/20 0.46
HTT P42858 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
RAD52 P43351 1/20 0.45
CHRNB2 P17787 1/20 0.43
CHRNA4 P43681 1/20 0.43
MMP12 P39900 2/20 0.42
HDAC6 Q9UBN7 1/20 0.42
CYP3A4 P08684 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14723315 0.83 MAPT (0.56) MAPTALDH1A1KDM4ETDP1APEX1
SCHEMBL13373332 0.83 MAPT (0.48) MAPTALDH1A1KDM4ETDP1APEX1
SCHEMBL3044280 0.83 MAPT (0.61) MAPTALDH1A1KDM4ETDP1APEX1
SCHEMBL31150482 0.83 MAPT (0.56) MAPTALDH1A1KDM4ETDP1APEX1
SCHEMBL3050263 0.83 MAPT (0.48) MAPTALDH1A1KDM4ETDP1APEX1
SCHEMBL23124230 0.83 MAPT (0.61) MAPTALDH1A1KDM4ETDP1APEX1
SCHEMBL31444162 0.83 MAPT (0.48) MAPTALDH1A1KDM4ETDP1APEX1
SCHEMBL31153163 0.83 MAPT (0.61) MAPTALDH1A1KDM4ETDP1APEX1
SCHEMBL14511179 0.82 MAPT (0.68) MAPTALDH1A1KDM4ETDP1APEX1
SCHEMBL12445185 0.79 MAPT (0.65) MAPTALDH1A1KDM4ETDP1APEX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-119287465-A Wear-resistant duplex stainless steel belt and processing technology thereof 江苏甬金金属科技有限公司 2025-01-10 CN claimed
CN-118164917-A Alpha-fluoroenamine compound and preparation method and application thereof 南京工业大学 2024-06-11 CN claimed
CN-119287465-A Wear-resistant duplex stainless steel belt and processing technology thereof 江苏甬金金属科技有限公司 2025-01-10 CN disclosed
CN-118164917-A Alpha-fluoroenamine compound and preparation method and application thereof 南京工业大学 2024-06-11 CN disclosed
CN-115651206-B Cage-shaped synthetic supermolecular material, preparation method and application thereof 广州大学 2023-11-24 CN disclosed
CN-115651206-A Cage-shaped synthetic supramolecular material, preparation method and application thereof 广州大学 2023-01-31 CN disclosed
CN-110191882-B Heterocyclic compounds, process for their preparation and pharmaceutical compositions containing them 株式会社大熊制药 2022-09-13 CN disclosed
US-10981917-B2 Heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same DAEWOONG PHARMACEUTICAL CO., LTD. (KR) 2021-04-20 US disclosed
WO-2020247160-A1 CONDENSED TRYCICLIC PYRROLES AS ALPHA-1 ANTITRYPSIN MODULATORS VERTEX PHARMACEUTICALS INCORPORATED (US) 2020-12-10 WO disclosed
EP-3159335-B1 NOVEL HETEROCYCLIC COMPOUND DAE WOONG PHARMA (KR) 2020-04-29 EP disclosed
US-10081634-B2 Heterocyclic compound DAEWOONG PHARMACEUTICAL CO., LTD. (KR) 2018-09-25 US disclosed
EP-2935244-B1 NOVEL BENZIMIDAZOLE DERIVATIVES AS KINASE INHIBITORS SELVITA S A (PL) 2018-06-27 EP disclosed
US-20180062213-A1 Nonaqueous Electrolyte and Nonaqueous Secondary Battery ASAHI KASEI KABUSHIKI KAISHA (JP) 2018-03-01 US disclosed
EP-3279997-A1 NONAQUEOUS ELECTROLYTE AND NONAQUEOUS SECONDARY BATTERY Asahi Kasei Kabushiki Kaisha (JP) 2018-02-07 EP disclosed
EP-3159335-A2 NOVEL HETEROCYCLIC COMPOUND Daewoong Pharmaceutical Co., Ltd. (KR) 2017-04-26 EP disclosed
US-20170088551-A1 NOVEL HETEROCYCLIC COMPOUND Daewoong Pharmaceutical., Ltd. (KR) 2017-03-30 US disclosed
WO-1999051619-A1 ARABINOFURANOSYL BENZIMIDAZOLES AS ANTIVIRAL AGENTS THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 1999-10-14 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10981917-B2 Heterocyclic compound, its preparation method, and pharmaceutical composition comprising the same RNASE1, AARS1, DHPS MAPT 3729/4885ALDH1A1 2364/4885KDM4E 3070/4885
US-10081634-B2 Heterocyclic compound AARS1, NSUN3, RNASE1 MAPT 3681/4885ALDH1A1 1349/4885KDM4E 3488/4885
US-20180062213-A1 Nonaqueous Electrolyte and Nonaqueous Secondary Battery BPTF, BRD4, KCNN2 MAPT 1283/4885ALDH1A1 3497/4885KDM4E 2256/4885
US-20170088551-A1 NOVEL HETEROCYCLIC COMPOUND AARS1, TARBP1, NSUN3 MAPT 3773/4885ALDH1A1 2054/4885KDM4E 3544/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.