SCHEMBL8370885

SCHEMBL8370885

[CH2]c1cccc(N[C@H](C(C)C)S(=O)(=O)c2ccc3[nH]c(NC(=O)OC)nc3c2)c1O

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACR P10323 1/20 0.43
LMNA P02545 7/20 0.40
CYP1A2 P05177 5/20 0.40
HIF1A Q16665 5/20 0.40
SMN1; SMN2 Q16637 2/20 0.40
CYP2C19 P33261 1/20 0.40
TUBB4A P04350 6/20 0.40
TUBB P07437 6/20 0.40
TUBA3C P0DPH7 6/20 0.40
TUBA1B P68363 6/20 0.40
TUBA4A P68366 6/20 0.40
TUBB4B P68371 6/20 0.40
TUBB3 Q13509 6/20 0.40
TUBB2A Q13885 6/20 0.40
TUBB8 Q3ZCM7 6/20 0.40
TUBA3E Q6PEY2 6/20 0.40
TUBA1A Q71U36 6/20 0.40
TUBA1C Q9BQE3 6/20 0.40
TUBB6 Q9BUF5 6/20 0.40
TUBB2B Q9BVA1 6/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8517147 0.76 ACR (0.54) ACRLMNACYP1A2HIF1ASMN1; SMN2
SCHEMBL5981885 0.72 ADAMTS4 (0.34) LMNATUBB4ATUBBTUBA3CTUBA1B
SCHEMBL10742942 0.72 ACR (0.53) ACRLMNACYP1A2HIF1ASMN1; SMN2
SCHEMBL7247709 0.72 ACR (0.43) ACRLMNACYP1A2HIF1ASMN1; SMN2
SCHEMBL10627091 0.72 LMNA (0.56) ACRLMNACYP1A2HIF1ASMN1; SMN2
SCHEMBL8779479 0.72 ACR (0.42) ACRLMNACYP1A2HIF1ASMN1; SMN2
SCHEMBL4862487 0.71 ACR (0.52) ACRLMNACYP1A2HIF1ASMN1; SMN2
Hydrochloric Acid SCHEMBL11094182 0.71 ACR (0.52) ACRLMNACYP1A2HIF1ASMN1; SMN2
SCHEMBL11094785 0.71 ACR (0.52) ACRLMNACYP1A2HIF1ASMN1; SMN2
SCHEMBL11094782 0.71 ACR (0.52) ACRLMNACYP1A2HIF1ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0893480-A1 Curable fluorosilicone composition having surface lubricity DOW CORNING CORPORATION (US) 1999-01-27 EP claimed