Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | NOS1 | P29475 | 1/20 | 0.40 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7027687 | 0.95 | CYP4F2 (0.50) | ALDH1A1TSHRCYP4F2CYP4A11KMT2A | |
| SCHEMBL15618416 | 0.93 | BCHE (0.49) | ALDH1A1TSHRCYP4F2CYP4A11KMT2A | |
| SCHEMBL834162 | 0.89 | ALDH1A1 (0.50) | ALDH1A1TSHRCYP4F2CYP4A11KMT2A | |
| SCHEMBL10356301 | 0.83 | LPL (0.46) | ALDH1A1TSHRKMT2AL3MBTL1CNR1 | |
| SCHEMBL6559558 | 0.82 | BCHE (0.49) | ALDH1A1TSHRCYP4F2CYP4A11KMT2A | |
| SCHEMBL11404905 | 0.81 | KMT2A (0.43) | ALDH1A1TSHRKMT2AL3MBTL1CNR1 | |
| SCHEMBL27332 | 0.80 | ALDH1A1 (0.54) | ALDH1A1TSHRKMT2AL3MBTL1CNR1 | |
| Hydrochloric Acid SCHEMBL6560552 | 0.80 | KMT2A (0.42) | ALDH1A1TSHRKMT2AL3MBTL1CNR1 | |
| SCHEMBL4593938 | 0.80 | ALDH1A1 (0.49) | ALDH1A1TSHRKMT2AL3MBTL1CNR1 | |
| SCHEMBL241880 | 0.80 | CYP4F2 (0.53) | CYP4F2CYP4A11KMT2AALOX15NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113880721-A | Synthetic method of dapoxetine | 湖南九典制药股份有限公司 | 2022-01-04 | — | — | CN | claimed |
| CN-107935868-A | A kind of crystal form of 5 hydroxytryptamine reuptake inhibithors and preparation method thereof | 广州白云山医药集团股份有限公司白云山制药总厂 | 2018-04-20 | — | — | CN | claimed |
| CN-106883133-A | A kind of preparation method of dapoxetine hydrochloride | 南京斯贝源医药科技有限公司 | 2017-06-23 | — | — | CN | claimed |
| CN-106748825-A | A kind of synthesis of Dapoxetine hydrochloride, resolving and purifying and salifying method | 聊城大学 | 2017-05-31 | — | — | CN | claimed |
| CN-113880721-A | Synthetic method of dapoxetine | 湖南九典制药股份有限公司 | 2022-01-04 | — | — | CN | disclosed |
| CN-113880721-A | Synthetic method of dapoxetine | 湖南九典制药股份有限公司 | 2022-01-04 | — | — | CN | disclosed |
| CN-106883133-B | A kind of preparation method of dapoxetine hydrochloride | 南京斯贝源医药科技有限公司 | 2019-12-03 | — | — | CN | disclosed |
| CN-107935868-A | A kind of crystal form of 5 hydroxytryptamine reuptake inhibithors and preparation method thereof | 广州白云山医药集团股份有限公司白云山制药总厂 | 2018-04-20 | — | — | CN | disclosed |
| CN-106883133-A | A kind of preparation method of dapoxetine hydrochloride | 南京斯贝源医药科技有限公司 | 2017-06-23 | — | — | CN | disclosed |
| CN-106748825-A | A kind of synthesis of Dapoxetine hydrochloride, resolving and purifying and salifying method | 聊城大学 | 2017-05-31 | — | — | CN | disclosed |
| CN-104610076-B | A kind of S-dapoxetine and the synthetic method of salt thereof | 湖南中医药大学 | 2016-11-23 | — | — | CN | disclosed |
| CN-103373931-B | The industrialized process for preparing of a kind of dapoxetine and intermediate thereof | CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO., LTD. (CN) | 2016-04-13 | — | — | CN | disclosed |
| WO-2014023258-A1 | PYRAZOLE CARBOXAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F.HOFFMANN-LA ROCHE AG (CH) | 2014-02-13 | — | — | WO | disclosed |
| CN-103373931-A | Industrial preparation method of apoxetine and intermediate of apoxetine | CHONGQING PHARM RES INST CO | 2013-10-30 | — | — | CN | disclosed |
| WO-2013024011-A1 | INDAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | F. HOFFMANN-LA ROCHE AG (CH) | 2013-02-21 | — | — | WO | disclosed |
| CN-101875666-B | Optical pure 1,3-alkamine compound as well as preparation method and application thereof in preparing Dapoxetine and analogues thereof | ASTATECH CHENGDU PHARMACEUTICAL CO LTD | 2011-12-28 | — | — | CN | disclosed |
| CN-101875666-A | Optical pure 1,3-alkamine compound as well as preparation method and application thereof in preparing Dapoxetine and analogues thereof | ASTATECH CHENGDU PHARMACEUTICAL CO LTD | 2010-11-03 | — | — | CN | disclosed |
| WO-1999067196-A1 | FLUOXETINE PROCESS FROM BENZOYLPROPIONIC ACID | SEPRACOR INC. (US) | 1999-12-29 | — | — | WO | disclosed |
| US-4970232-A | CALCIUM CHANNEL BLOCKERS; ANOXIA, ANTIEPILEPTIC AND ANTIISCHEMIC AGENTS; HEADACHES | A/S FERROSAN (DK) | 1990-11-13 | — | — | US | disclosed |
| EP-0031910-A1 | Aniline derivatives, pharmaceutical preparations containing them and processes for their production | MERCK PATENT GmbH (DE) | 1981-07-15 | — | — | EP | disclosed |