Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | NOS1 | P29475 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | CHKA | P35790 | 3/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10356301 | 0.81 | LPL (0.46) | KMT2AL3MBTL1ALDH1A1TSHRCNR1 | |
| SCHEMBL11404905 | 0.80 | KMT2A (0.43) | KMT2AL3MBTL1ALDH1A1TSHRCNR1 | |
| SCHEMBL8374276 | 0.80 | ALDH1A1 (0.47) | KMT2AL3MBTL1ALDH1A1TSHRCNR1 | |
| SCHEMBL7027687 | 0.79 | CYP4F2 (0.50) | KMT2AL3MBTL1ALDH1A1TSHRCNR1 | |
| SCHEMBL7027684 | 0.77 | L3MBTL1 (0.41) | KMT2AL3MBTL1ALDH1A1TSHRCNR1 | |
| SCHEMBL15618416 | 0.77 | BCHE (0.49) | KMT2AL3MBTL1ALDH1A1TSHRCNR1 | |
| SCHEMBL169805 | 0.77 | ALDH1A1 (0.47) | KMT2AL3MBTL1ALDH1A1TSHRCNR1 | |
| SCHEMBL6560546 | 0.76 | CNR1 (0.45) | KMT2AL3MBTL1ALDH1A1TSHRCNR1 | |
| SCHEMBL7027577 | 0.76 | SIGMAR1 (0.42) | KMT2AL3MBTL1ALDH1A1TSHRCNR1 | |
| SCHEMBL6750529 | 0.76 | CALM1 (0.53) | KMT2AL3MBTL1ALDH1A1TSHRCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1132409-B1 | Catalyst systems for the Ziegler-Natta-Olefin-Polymerisation | MERCK PATENT GMBH (DE) | 2004-06-30 | — | — | EP | claimed |
| US-6534606-B2 | Aluminium alkyl complexes applied to magnesium chloride and/or silicon dioxide as support in the presence of titanium or vanadium halides and donors act as cocatalysts and stereoselectivity promoters | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2003-03-18 | — | — | US | claimed |
| US-20020173603-A1 | Catalyst system for the Ziegler-Natta polymerization of olefins | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-11-21 | — | — | US | claimed |
| US-6534606-B2 | Aluminium alkyl complexes applied to magnesium chloride and/or silicon dioxide as support in the presence of titanium or vanadium halides and donors act as cocatalysts and stereoselectivity promoters | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2003-03-18 | — | — | US | disclosed |
| US-20020173603-A1 | Catalyst system for the Ziegler-Natta polymerization of olefins | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-11-21 | — | — | US | disclosed |