Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CCR9 | P51686 | 1/20 | 0.45 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GALK1 | P51570 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6086516 | 0.86 | CA1 (0.51) | CA1CA2MEN1KMT2AKDM4E | |
| SCHEMBL6088751 | 0.86 | KIF11 (0.56) | SMN1; SMN2ALDH1A1MAPK1KIF11CA1 | |
| SCHEMBL6087435 | 0.74 | CA1 (0.54) | SMN1; SMN2ALDH1A1MAPK1KIF11CA1 | |
| SCHEMBL6673886 | 0.71 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1MAPK1KIF11CA1 | |
| SCHEMBL7570513 | 0.71 | FFAR4 (0.64) | SMN1; SMN2ALDH1A1MAPK1KIF11CA1 | |
| SCHEMBL9517004 | 0.70 | TP53 (0.57) | SMN1; SMN2ALDH1A1MAPK1KIF11MEN1 | |
| SCHEMBL7570765 | 0.70 | CES1 (0.67) | SMN1; SMN2ALDH1A1IDH1TP53HDAC1 | |
| SCHEMBL23674890 | 0.70 | KIF11 (0.65) | SMN1; SMN2ALDH1A1MAPK1KIF11KMT2A | |
| SCHEMBL6086454 | 0.70 | CA1 (0.64) | ALDH1A1KIF11CA1CA2 | |
| SCHEMBL20847671 | 0.69 | CA1 (0.68) | ALDH1A1MAPK1CA1CA2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5880151-A | TREATING OR PREVENTING DISEASE CHARACTERIZED BY HIGH LEVELS OF LOW DENSITY LIPOPROTEIN PARTICLES OR CHOLESTEROL IN BLOOD | TULARIK INC. (US) | 1999-03-09 | — | — | US | claimed |