SCHEMBL8375486

SCHEMBL8375486

Cc1ccccc1Oc1ccc(O)cc1C

nearest known ligand 0.52

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.47
KMT2A Q03164 2/20 0.47
NPC1 O15118 1/20 0.47
TSHR P16473 1/20 0.47
RAB9A P51151 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
AR P10275 2/20 0.46
ESR2 Q92731 1/20 0.46
SLC6A2 P23975 3/20 0.41
SLC6A4 P31645 3/20 0.41
SLC6A3 Q01959 3/20 0.41
CYP1A2 P05177 1/20 0.40
CYP2C19 P33261 1/20 0.40
HTR1A P08908 1/20 0.39
HTR3A P46098 1/20 0.39
MAPT P10636 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5032967 0.89 CYP3A4 (0.44) TSHRESR2
SCHEMBL2865455 0.86 MAOB (0.53) MEN1KMT2ANPC1TSHRRAB9A
SCHEMBL7220532 0.83 ESRRA (0.46) ESR2
SCHEMBL9853725 0.83 ESR2 (0.59) ESR2MAPT
SCHEMBL5082815 0.82 LTA4H (0.52) TSHRARESR2
SCHEMBL8374404 0.80 MEN1 (0.47) MEN1KMT2ANPC1TSHRRAB9A
SCHEMBL127000 0.80 TSHR (0.65) MEN1KMT2ANPC1TSHRRAB9A
SCHEMBL29637724 0.80 TSHR (0.65) MEN1KMT2ANPC1TSHRRAB9A
SCHEMBL8737305 0.79 HTR1A (0.55) MEN1KMT2ANPC1TSHRRAB9A
SCHEMBL9853726 0.78 KMT2A (0.50) MEN1KMT2ASMN1; SMN2SLC6A2SLC6A3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0659801-B1 Polyimide MITSUI CHEMICALS INC (JP) 1999-03-10 EP disclosed
US-5484880-A HEAT RESISTANT POLYMERS FOR APPLIANCES AND INJECTION MOLDED ARTICLES OR FILMS MITSUI TOATSU CHEMICALS, INC. (JP) 1996-01-16 US disclosed
EP-0659801-A1 Polyimide MITSUI TOATSU CHEMICALS, Inc. (JP) 1995-06-28 EP disclosed