Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 6/20 | 0.53 |
| ▸ | RAB9A | P51151 | 6/20 | 0.53 |
| ▸ | CDH1 | P12830 | 1/20 | 0.49 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.49 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11280000 | 0.81 | NPC1 (0.53) | NOTUMNPC1RAB9ACDH1CTNNB1 | |
| SCHEMBL10869005 | 0.77 | SMN1; SMN2 (0.55) | NOTUMNPC1RAB9ACDH1CTNNB1 | |
| SCHEMBL6938529 | 0.77 | NOTUM (0.61) | NOTUMNPC1RAB9ACDH1CTNNB1 | |
| Acetic Acid Methyl Ester SCHEMBL9550215 | 0.75 | CDH1 (0.50) | NOTUMNPC1RAB9ACDH1CTNNB1 | |
| SCHEMBL11283034 | 0.75 | THRB (0.50) | NOTUMNPC1RAB9ACDH1CTNNB1 | |
| SCHEMBL18489825 | 0.75 | NPC1 (0.86) | NOTUMNPC1RAB9AMAPTHPGD | |
| SCHEMBL11285150 | 0.74 | RAB9A (0.64) | NPC1RAB9ASMN1; SMN2MAPTL3MBTL1 | |
| SCHEMBL16401815 | 0.73 | NPC1 (0.56) | NOTUMNPC1RAB9ACDH1CTNNB1 | |
| SCHEMBL11276075 | 0.73 | NPC1 (0.56) | NOTUMNPC1RAB9ACDH1CTNNB1 | |
| SCHEMBL7904001 | 0.73 | MAPT (0.64) | NOTUMNPC1RAB9ACDH1CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6005116-A | HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA | SANKYO COMPANY, LIMITED (JP) | 1999-12-21 | — | — | US | disclosed |
| EP-0885891-A1 | ISOXAZOLE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |