Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8375792 | 1.00 | SMN1; SMN2 (0.50) | SMN1; SMN2ALDH1A1GAATDP1MAPT | |
| SCHEMBL8375080 | 0.84 | LMNA (0.43) | SMN1; SMN2ALDH1A1GAAMAPTCYP1A2 | |
| SCHEMBL8375083 | 0.84 | LMNA (0.43) | SMN1; SMN2ALDH1A1GAAMAPTCYP1A2 | |
| SCHEMBL11821119 | 0.83 | ALDH1A1 (0.56) | SMN1; SMN2ALDH1A1GAATDP1MAPT | |
| SCHEMBL1054614 | 0.83 | ALDH1A1 (0.56) | SMN1; SMN2ALDH1A1GAATDP1MAPT | |
| SCHEMBL8375834 | 0.80 | NPSR1 (0.51) | ALDH1A1MAPTCES2CES1GSK3B | |
| SCHEMBL8375832 | 0.80 | NPSR1 (0.51) | ALDH1A1MAPTCES2CES1GSK3B | |
| SCHEMBL1525403 | 0.79 | CES2 (0.57) | SMN1; SMN2ALDH1A1GAATDP1MAPT | |
| SCHEMBL8377288 | 0.78 | NPC1 (0.51) | SMN1; SMN2ALDH1A1MAPTPPARAKMT2A | |
| SCHEMBL8377289 | 0.78 | NPC1 (0.51) | SMN1; SMN2ALDH1A1MAPTPPARAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6005116-A | HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA | SANKYO COMPANY, LIMITED (JP) | 1999-12-21 | — | — | US | disclosed |
| EP-0885891-A1 | ISOXAZOLE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |