Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | SRD5A2 | P31213 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8377288 | 1.00 | NPC1 (0.51) | NPC1RAB9AHPGDCRHBPCRHR2 | |
| SCHEMBL11821119 | 0.88 | ALDH1A1 (0.56) | NPC1SMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL1054614 | 0.88 | ALDH1A1 (0.56) | NPC1SMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL4739675 | 0.81 | ALDH1A1 (0.57) | NPC1RAB9AHPGDCRHBPCRHR2 | |
| SCHEMBL6340266 | 0.79 | ALDH1A1 (0.54) | NPC1RAB9AHPGDCRHBPCRHR2 | |
| SCHEMBL8375792 | 0.78 | SMN1; SMN2 (0.50) | HPGDSMN1; SMN2ALDH1A1MAPTHTT | |
| SCHEMBL8375797 | 0.78 | SMN1; SMN2 (0.50) | HPGDSMN1; SMN2ALDH1A1MAPTHTT | |
| SCHEMBL1730420 | 0.78 | SMN1; SMN2 (0.66) | NPC1RAB9AHPGDCRHBPCRHR2 | |
| SCHEMBL6157109 | 0.77 | SMN1; SMN2 (0.52) | NPC1RAB9AHPGDCRHBPCRHR2 | |
| SCHEMBL6157660 | 0.77 | SMN1; SMN2 (0.52) | NPC1RAB9AHPGDCRHBPCRHR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6005116-A | HAVE INHIBITION ACTIVITIES AGAINST TYPE A-MONOAMINE OXIDASE; TREATING OR PREVENTING DEPRESSION, PARKINSON'S DISEASE, ALZEHEIMER'S DEMENTIA, OR CEREBROVASCULAR DEMENTIA | SANKYO COMPANY, LIMITED (JP) | 1999-12-21 | — | — | US | disclosed |
| EP-0885891-A1 | ISOXAZOLE DERIVATIVES | SANKYO COMPANY LIMITED (JP) | 1998-12-23 | — | — | EP | disclosed |