Sugi Predict

Sugi Predict / Compounds / SCHEMBL837583

SCHEMBL837583

SCHEMBL837583

CCOC(OCC)C(=O)c1ccc(F)cc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ SLC6A2 P23975 1/20 0.46
▸ SLC6A3 Q01959 1/20 0.46
▸ HTR7 P34969 1/20 0.46
▸ MAPT P10636 3/20 0.45
▸ KMT2A Q03164 3/20 0.45
▸ MEN1 O00255 2/20 0.45
▸ CASP3 P42574 1/20 0.45
▸ TRPV1 Q8NER1 1/20 0.45
▸ SENP7 Q9BQF6 1/20 0.45
▸ CES2 O00748 1/20 0.45
▸ CES1 P23141 1/20 0.45
▸ ALDH1A1 P00352 2/20 0.44
▸ HPGD P15428 1/20 0.44
▸ PTPN1 P18031 1/20 0.42
▸ NPC1 O15118 1/20 0.42
▸ RAB9A P51151 1/20 0.42
▸ CA1 P00915 2/20 0.42
▸ CA2 P00918 2/20 0.42
▸ MAOB P27338 2/20 0.42
▸ LMNA P02545 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11362698 0.90 CA12 (0.42) MAPTKMT2AMEN1ALDH1A1HPGD
SCHEMBL10947299 0.84 RAB9A (0.44) MAPTKMT2AALDH1A1HPGDNPC1
SCHEMBL10943532 0.84 CES2 (0.43) MAPTCES2CES1ALDH1A1NPC1
SCHEMBL5696485 0.84 SLC6A2 (0.43) SLC6A2SLC6A3HTR7MAPTKMT2A
SCHEMBL6426469 0.82 ESR1 (0.55) SLC6A2SLC6A3MAPTKMT2AMEN1
SCHEMBL9160725 0.82 ALDH1A1 (0.46) SLC6A2SLC6A3KMT2AMEN1CES2
SCHEMBL5578202 0.81 CES2 (0.52) HTR7MAPTKMT2AMEN1CASP3
SCHEMBL6982165 0.81 CXCR1 (0.46) SLC6A2SLC6A3MAPTKMT2AMEN1
SCHEMBL15309561 0.81 SLC6A2 (0.46) SLC6A2SLC6A3MAPTKMT2AMEN1
SCHEMBL11362797 0.81 HPGD (0.50) MAPTKMT2AALDH1A1HPGDNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250223291-A1 IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS INCYTE CORPORATION 2025-07-10 — — US disclosed
US-12084449-B2 Imidazotriazines and imidazopyrimidines as kinase inhibitors INCYTE HOLDINGS CORPORATION (US) 2024-09-10 — — US disclosed
US-20230002392-A1 Imidazotriazines and Imidazopyrimidines as Kinase Inhibitors INCYTE CORPORATION 2023-01-05 — — US disclosed
US-11261191-B2 Imidazotriaines and imidazopyrimidines as kinase inhibitors INCYTE HOLDINGS CORPORATION (US) 2022-03-01 — — US disclosed
US-20200317680-A1 Imidazotriaines and Imidazopyrimidines as Kinase Inhibitors INCYTE HOLDINGS CORPORATION 2020-10-08 — — US disclosed
US-10738052-B2 Imidazotriaines and imidazopyrimidines as kinase inhibitors INCYTE HOLDINGS CORPORATION (US) 2020-08-11 — — US disclosed
EP-3443958-A1 IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS Incyte Holdings Corporation (US) 2019-02-20 — — EP disclosed
US-20180282340-A1 Imidazotriaines and Imidazopyrimidines as Kinase Inhibitors INCYTE CORPORATION 2018-10-04 — — US disclosed
EP-3034075-B1 IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS INCYTE HOLDINGS CORP (US) 2018-07-25 — — EP disclosed
US-9944645-B2 Imidazotriazines and imidazopyrimidines as kinase inhibitors INCYTE CORPORATION (US) 2018-04-17 — — US disclosed
US-5008302-A Photoinitiators for radiation-induced polymerization of ethylenically unsaturated compounds CIBA-GEIGY CORPORATION (US) 1991-04-16 — — US disclosed
EP-0401166-A2 Nitrogen-containing titanocenes and their use CIBA-GEIGY AG (CH) 1990-12-05 — — EP disclosed
EP-0401165-A1 New oxygen-containing titanocenes and their use CIBA-GEIGY AG (CH) 1990-12-05 — — EP disclosed
US-4970136-A PHOTOINITIATORS CIBA-GEIGY CORPORATION (US) 1990-11-13 — — US disclosed
US-4963470-A PHOTOINITIATORS CIBA-GEIGY CORPORATION (US) 1990-10-16 — — US disclosed
EP-0242330-B1 LIQUID BLEND OF PHOTOINITIATORS CIBA-GEIGY AG (CH) 1990-05-16 — — EP disclosed
EP-0318893-A2 Titanocenes, their use and N-substituted fluoroanilines CIBA-GEIGY AG (CH) 1989-06-07 — — EP disclosed
EP-0318894-A2 Titanocenes, their use and N-substituted pyrroles CIBA-GEIGY AG (CH) 1989-06-07 — — EP disclosed
EP-0256981-A2 Titanocenes and their use CIBA-GEIGY AG (CH) 1988-02-24 — — EP disclosed
EP-0242330-A1 Liquid blend of photoinitiators CIBA-GEIGY AG (CH) 1987-10-21 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230002392-A1 Imidazotriazines and Imidazopyrimidines as Kinase Inhibitors ERBB2, MERTK, ABL1 SLC6A2 4327/4885SLC6A3 4033/4885HTR7 1599/4885
US-20180282340-A1 Imidazotriaines and Imidazopyrimidines as Kinase Inhibitors MET, RET, ERBB2 SLC6A2 4409/4885SLC6A3 4238/4885HTR7 1458/4885
US-20250223291-A1 IMIDAZOTRIAZINES AND IMIDAZOPYRIMIDINES AS KINASE INHIBITORS ERBB2, MERTK, ABL1 SLC6A2 4327/4885SLC6A3 4033/4885HTR7 1599/4885
US-20200317680-A1 Imidazotriaines and Imidazopyrimidines as Kinase Inhibitors MET, RET, ERBB2 SLC6A2 4409/4885SLC6A3 4238/4885HTR7 1458/4885
US-12084449-B2 Imidazotriazines and imidazopyrimidines as kinase inhibitors ERBB2, MERTK, ABL1 SLC6A2 4327/4885SLC6A3 4033/4885HTR7 1599/4885
US-11261191-B2 Imidazotriaines and imidazopyrimidines as kinase inhibitors MET, RET, ERBB2 SLC6A2 4409/4885SLC6A3 4238/4885HTR7 1458/4885
US-10738052-B2 Imidazotriaines and imidazopyrimidines as kinase inhibitors MET, RET, ERBB2 SLC6A2 4409/4885SLC6A3 4238/4885HTR7 1458/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.