Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8377486 | 0.92 | ALDH1A1 (0.37) | KMT2AMEN1ADRA1ADRD3MAPT | |
| SCHEMBL8554624 | 0.92 | MAPT (0.39) | KMT2AMEN1KCNH2MAPTALDH1A1 | |
| SCHEMBL8377057 | 0.90 | MEN1 (0.35) | KMT2AMEN1CHRM2HTR1AADRA2A | |
| SCHEMBL8378712 | 0.89 | DRD3 (0.39) | KMT2AMEN1CHRM2HTR1AADRA2A | |
| SCHEMBL8375935 | 0.86 | MAPT (0.38) | KMT2AMEN1CHRM2HTR1AADRA2A | |
| SCHEMBL8373704 | 0.85 | MAPT (0.40) | KMT2AMEN1MAPTALDH1A1HSP90AA1 | |
| SCHEMBL8517128 | 0.85 | MAPT (0.37) | KMT2AMEN1CHRM2HTR1AADRA2A | |
| SCHEMBL8373739 | 0.82 | BCHE (0.35) | HTR1AADRA1ADRD3BCHEHTR2C | |
| SCHEMBL8373804 | 0.81 | HTR1A (0.40) | KMT2AMEN1CHRM2HTR1AADRA2A | |
| SCHEMBL8377619 | 0.80 | DRD2 (0.36) | HTR1AADRA1ADRD3HTR2CHRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900199-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1999-03-10 | — | — | EP | claimed |
| WO-1997041099-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-11-06 | — | — | WO | claimed |
| EP-0900199-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1999-03-10 | — | — | EP | disclosed |
| WO-1997041099-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-11-06 | — | — | WO | disclosed |