SCHEMBL8376178

SCHEMBL8376178

CCC(=O)Oc1cc(-n2nc3ccc(Cl)cc3n2)c(O)c(C(C)(C)C)c1

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NR1H4 Q96RI1 1/20 0.36
MAPT P10636 5/20 0.35
NPC1 O15118 6/20 0.34
RAB9A P51151 5/20 0.34
KDM4E B2RXH2 4/20 0.34
ALDH1A1 P00352 4/20 0.34
HPGD P15428 3/20 0.34
TDP1 Q9NUW8 2/20 0.34
CYP1A2 P05177 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
GAA P10253 1/20 0.32
MAPK1 P28482 1/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
VCAM1 P19320 1/20 0.32
NPSR1 Q6W5P4 1/20 0.31
L3MBTL1 Q9Y468 1/20 0.31
IDE P14735 1/20 0.31
RXFP1 Q9HBX9 1/20 0.31
POLB P06746 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8377382 0.92 NR1H4 (0.35) NR1H4MAPTNPC1RAB9AKDM4E
SCHEMBL28646965 0.88 VCAM1 (0.38) NPC1RAB9AALDH1A1HPGDTDP1
SCHEMBL8377454 0.88 VCAM1 (0.38) NPC1RAB9AALDH1A1HPGDTDP1
SCHEMBL8580605 0.88 NPC1 (0.43) MAPTNPC1RAB9AKDM4EALDH1A1
SCHEMBL29791013 0.88 NPC1 (0.43) MAPTNPC1RAB9AKDM4EALDH1A1
SCHEMBL22283789 0.85 NR1H4 (0.36) NR1H4MAPTNPC1RAB9AKDM4E
SCHEMBL8384145 0.84 GAA (0.38) NR1H4MAPTNPC1RAB9AKDM4E
SCHEMBL31025700 0.84 MEN1 (0.35) MAPTNPC1RAB9AKDM4EALDH1A1
SCHEMBL12199840 0.83 CA1 (0.48) NR1H4MAPTNPC1RAB9AKDM4E
SCHEMBL21586951 0.82 PDE2A (0.35) NR1H4MAPTNPC1RAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113614581-A Method for producing optical material, and polymerizable composition for optical material 三井化学株式会社 2021-11-05 CN disclosed
US-5914361-A IMPART HEAT STABILITY TO ORGANIC MATERIALS, INCLUDING POLYOLEFINS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-06-22 US disclosed
US-5902516-A STABILIZER FOR THERMOPLASTIC POLYOLEFIN OR ENGINEERING RESINS SUMITOMO CHEMICAL CO., LTD (JP) 1999-05-11 US disclosed
US-5891939-A POLYMER STABILIZERS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-04-06 US disclosed
US-5874494-A DETERIORATION STABILIZER FOR THERMOPLASTIC RESIN; OXIDATION RESISTANCE, DISCOLORATION INHIBITION, HEAT RESISTANCE, CROSSLINKING INHIBITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1999-02-23 US disclosed
US-5847187-A Organic phosphorous compound, a process for producing the same and a use thereof SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-12-08 US disclosed
US-5843339-A Phosphites and their production and use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-12-01 US disclosed
US-5830936-A THERMAL STABILIZERS FOR POLYOLEFINS AND ENGINEERING PLASTICS SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1998-11-03 US disclosed