SCHEMBL8376286

SCHEMBL8376286

CCC(c1cc(Cl)c(O)c(Br)c1)c1cc(Cl)c(O)c(Br)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 4/20 0.42
CYP2C19 P33261 3/20 0.42
ALOX15 P16050 3/20 0.42
ALOX12 P18054 3/20 0.42
HIF1A Q16665 3/20 0.42
CYP1A2 P05177 2/20 0.42
SMN1; SMN2 Q16637 2/20 0.42
CYP2C9 P11712 1/20 0.42
ERN1 O75460 1/20 0.34
CYP3A4 P08684 8/20 0.33
SLC6A2 P23975 6/20 0.33
SLC6A4 P31645 6/20 0.33
SLC6A3 Q01959 5/20 0.33
KCNH2 Q12809 5/20 0.33
CYP2D6 P10635 4/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
HKDC1 Q2TB90 1/20 0.33
TSHR P16473 4/20 0.32
TTR P02766 3/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2415957 0.86 HSD17B10 (0.56) HSD17B10CYP2C19ALOX15ALOX12HIF1A
SCHEMBL2420908 0.86 TSHR (0.44) HSD17B10CYP2C19ALOX15ALOX12HIF1A
SCHEMBL10798549 0.86 CYP2C19 (0.39) HSD17B10CYP2C19ALOX15ALOX12HIF1A
SCHEMBL29077173 0.82 ALOX15 (0.56) HSD17B10CYP2C19ALOX15ALOX12HIF1A
SCHEMBL5296507 0.79 HSD17B10 (0.43) HSD17B10CYP2C19ALOX15ALOX12HIF1A
SCHEMBL4782428 0.79 ESR1 (0.35) HSD17B10CYP2C19ALOX15ALOX12HIF1A
SCHEMBL11142489 0.79 HSD17B10 (0.46) HSD17B10CYP2C19ALOX15ALOX12HIF1A
SCHEMBL30343466 0.78 HSD17B10 (0.70) HSD17B10CYP2C19ALOX15ALOX12HIF1A
SCHEMBL1596630 0.78 HSD17B10 (0.70) HSD17B10CYP2C19ALOX15ALOX12HIF1A
SCHEMBL5077373 0.76 GABRA1 (0.47) HSD17B10CYP2C19ALOX15ALOX12HIF1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0896975-A1 POLYCARBONATE, AND MOLDING AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR PREPARED THEREFROM IDEMITSU KOSAN COMPANY LIMITED (JP) 1999-02-17 EP disclosed
US-4414341-A DRY SPINNING CELANESE CORPORATION (US) 1983-11-08 US disclosed
US-4360662-A HALOPOLYESTER CELANESE CORPORATION (US) 1982-11-23 US disclosed
US-4354994-A Spinning process for antimony oxide/halogenated aromatic polyester composition CELANESE CORPORATION (US) 1982-10-19 US disclosed
US-4355152-A HEAT TREATMENT CELANESE CORPORATION (US) 1982-10-19 US disclosed
US-4346209-A HEAT TREATMENT AT CONSTANT LENGTH FOLLOWED BY TREATMENT WI HOT PERCHLOROETHYLENE CELANESE CORPORATION (US) 1982-08-24 US disclosed
US-4322521-A Process for producing halogenated aromatic polyesters CELANESE CORPORATION (US) 1982-03-30 US disclosed