Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.41 |
| ▸ | CES1 | P23141 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | KCNN4 | O15554 | 2/20 | 0.35 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.33 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8377598 | 1.00 | CES2 (0.41) | CES2CES1SLC6A3KCNN4CA12 | |
| SCHEMBL9044136 | 0.82 | KCNN4 (0.53) | CES2CES1KCNN4RIPK1NPC1 | |
| SCHEMBL12079275 | 0.82 | APP (0.45) | CES2CES1SLC6A3KCNN4CA12 | |
| SCHEMBL11278233 | 0.80 | MEN1 (0.47) | CES2CES1KCNN4MEN1NPC1 | |
| SCHEMBL29009976 | 0.80 | CES2 (0.39) | CES2CES1SLC6A3KCNN4CA12 | |
| SCHEMBL3941437 | 0.80 | CES2 (0.39) | CES2CES1SLC6A3KCNN4CA12 | |
| SCHEMBL3941432 | 0.80 | CES2 (0.39) | CES2CES1SLC6A3KCNN4CA12 | |
| Bromomethane SCHEMBL3181697 | 0.78 | CYP2C9 (0.41) | CES2CES1SLC6A3KCNN4CA12 | |
| SCHEMBL531511 | 0.77 | CES2 (0.52) | CES2APPRXRARXRBRXRG | |
| SCHEMBL5966766 | 0.74 | CES2 (0.42) | CES2CES1SLC6A3KCNN4CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090311318-A1 | SUBSTITUTED (S)-BENZOXAZINONES | P&H THERAPEUTICS, INC. (US) | 2009-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090311318-A1 | SUBSTITUTED (S)-BENZOXAZINONES | REN, ACE, AGTR1 | CES2 778/4885CES1 204/4885SLC6A3 149/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.