Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | BRD2 | P25440 | 1/20 | 0.32 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.32 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8379317 | 0.76 | CASP3 (0.38) | CASP3KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6740517 | 0.70 | POLB (0.46) | KDM4EMAPTOPRL1OPRM1 | |
| SCHEMBL8380654 | 0.70 | SRD5A1 (0.38) | NSD2OPRL1OPRM1 | |
| SCHEMBL3559706 | 0.69 | NSD2 (0.58) | NSD2 | |
| SCHEMBL23013861 | 0.69 | NOS3 (0.39) | KDM4EALDH1A1 | |
| SCHEMBL7394220 | 0.68 | KDM4E (0.41) | CASP3KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8377427 | 0.68 | NAMPT (0.41) | OPRL1OPRM1GABRA1GABRG2GABRB3 | |
| SCHEMBL7395289 | 0.68 | KDM4E (0.39) | CASP3KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL4781539 | 0.68 | KDM4E (0.48) | CASP3KDM4EALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7388593 | 0.68 | IDO1 (0.34) | KDM4EALDH1A1MAPTSMN1; SMN2NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5863947-A | Phenylglycine derivatives useful for treating disorders of the central nervous system | ELI LILLY AND COMPANY LIMITED (GB) | 1999-01-26 | — | — | US | disclosed |