SCHEMBL8378356

SCHEMBL8378356

CCn1ncc(C(=O)c2ccc(S(C)(=O)=O)c(N(C)C)c2Cl)c1O

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.36
RAB9A P51151 2/20 0.36
KMT2A Q03164 3/20 0.33
GAA P10253 2/20 0.33
NR3C1 P04150 1/20 0.32
LMNA P02545 2/20 0.32
ALDH1A1 P00352 2/20 0.31
HTT P42858 2/20 0.31
PRMT5 O14744 1/20 0.31
WDR77 Q9BQA1 1/20 0.31
MAPK14 Q16539 1/20 0.31
MAPT P10636 2/20 0.30
MEN1 O00255 1/20 0.30
POLB P06746 1/20 0.30
MAPK1 P28482 1/20 0.30
RECQL P46063 1/20 0.30
PAX8 Q06710 1/20 0.30
MCL1 Q07820 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30
L3MBTL1 Q9Y468 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1882413 0.89 LMNA (0.35) SMN1; SMN2RAB9AGAALMNAALDH1A1
SCHEMBL7962639 0.88 SMN1; SMN2 (0.39) SMN1; SMN2RAB9AKMT2AGAANR3C1
SCHEMBL9448454 0.85 SMN1; SMN2 (0.40) SMN1; SMN2RAB9AKMT2AGAANR3C1
SCHEMBL1965325 0.85 ALDH1A1 (0.32) RAB9AALDH1A1MAPTNPSR1
SCHEMBL12636818 0.85 GSTO1 (0.34) SMN1; SMN2RAB9ANR3C1CYP1A2CYP3A4
SCHEMBL8375883 0.84 SMN1; SMN2 (0.37) SMN1; SMN2RAB9AKMT2AGAANR3C1
SCHEMBL9078025 0.83 SMN1; SMN2 (0.36) SMN1; SMN2RAB9AKMT2AGAANR3C1
SCHEMBL9078372 0.83 SMN1; SMN2 (0.36) SMN1; SMN2RAB9AKMT2AGAANR3C1
SCHEMBL4497306 0.81 SMN1; SMN2 (0.39) SMN1; SMN2RAB9AKMT2AGAALMNA
SCHEMBL9076440 0.81 SMN1; SMN2 (0.35) SMN1; SMN2RAB9AGAALMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5962690-A HERBICIDES DOW AGROSCIENCES LLC (US) 1999-10-05 US disclosed