Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | METAP2 | P50579 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.42 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.41 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.41 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28477237 | 0.98 | IRAK4 (0.47) | IRAK4ALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL4114971 | 0.83 | IRAK4 (0.51) | IRAK4ALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL27433644 | 0.82 | ALDH1A1 (0.50) | ALDH1A1KDM4EHSD17B10MAPTHPGD | |
| SCHEMBL15190457 | 0.81 | IRAK4 (0.46) | IRAK4ALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL3736565 | 0.81 | IRAK4 (0.46) | IRAK4ALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL10659307 | 0.81 | ALDH1A1 (0.37) | IRAK4ALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL6850542 | 0.80 | CTSD (0.57) | ALDH1A1KDM4EHSD17B10MAPTTSHR | |
| SCHEMBL31632660 | 0.79 | IRAK4 (0.55) | IRAK4ALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL105262 | 0.79 | IRAK4 (0.55) | IRAK4ALDH1A1KDM4EHSD17B10MAPT | |
| SCHEMBL28132011 | 0.79 | IRAK4 (0.44) | IRAK4ALDH1A1KDM4EHSD17B10MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102532020-B | 5, 6, or 7-substituted -3-(hetero) arylisoquinolinamine derivatives | REXAHN PHARMACEUTICALS INC | 2015-02-25 | — | — | CN | disclosed |
| CN-103319408-A | Compounds for preventing and treating cardiovascular diseases | RESVERLOGIX CORP | 2013-09-25 | — | — | CN | disclosed |
| CN-101641339-B | Compounds for the prevention and treatment of cardiovascular diseases | RESVERLOGIX CORP | 2013-07-17 | — | — | CN | disclosed |
| CN-101641339-A | Compounds for the prevention and treatment of cardiovascular diseases | RESVERLOGIX CORP CA | 2010-02-03 | — | — | CN | disclosed |
| EP-0906268-A1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-04-07 | — | — | EP | disclosed |
| WO-1997045397-A1 | ALKYLOXYAMINO SUBSTITUTED FLUORENONES AND THEIR USE AS PROTEIN KINASE C INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1997-12-04 | — | — | WO | disclosed |