Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | EDNRA | P25101 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | HSPA1A | P0DMV8 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CASP6 | P55212 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8895580 | 0.82 | CYP2D6 (0.47) | TDP1ALDH1A1KMT2APOLBCYP2D6 | |
| SCHEMBL9321602 | 0.81 | GRM5 (0.46) | EPHX1TDP1ALDH1A1EDNRAKDM4E | |
| SCHEMBL7527637 | 0.81 | GRM5 (0.46) | EPHX1TDP1ALDH1A1EDNRAKDM4E | |
| SCHEMBL8895590 | 0.79 | CA1 (0.39) | TDP1ALDH1A1KDM4EHPGDALOX12 | |
| SCHEMBL8977701 | 0.72 | SLC6A2 (0.46) | EPHX1TDP1ALDH1A1KDM4EPKM | |
| SCHEMBL7899177 | 0.69 | CYP2C9 (0.43) | TDP1ALDH1A1KDM4EHSPA1APTPN7 | |
| SCHEMBL11546959 | 0.68 | CYP2D6 (0.46) | EPHX1TDP1ALDH1A1KDM4EKMT2A | |
| SCHEMBL7534121 | 0.68 | GRM5 (0.44) | EPHX1KDM4ERAB9AMAPTPOLB | |
| SCHEMBL6509232 | 0.66 | EDNRA (0.47) | ALDH1A1EDNRAKDM4EHPGDRAB9A | |
| SCHEMBL8345851 | 0.66 | SLC1A2 (0.30) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0425212-B1 | Cyclic anti-aggregatory peptides | SMITHKLINE BEECHAM CORP (US) | 1999-04-07 | — | — | EP | disclosed |
| EP-0425212-A2 | Cyclic anti-aggregatory peptides | SMITHKLINE BEECHAM CORPORATION (US) | 1991-05-02 | — | — | EP | disclosed |