Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 8/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 3/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8381006 | 0.83 | MAOB (0.53) | LTA4HSMN1; SMN2KIF11KCNH2 | |
| SCHEMBL8381114 | 0.81 | LTA4H (0.50) | LTA4HSMN1; SMN2KIF11KCNH2NPC1 | |
| SCHEMBL8391278 | 0.80 | KCNA3 (0.56) | LTA4HKCNA3RAB9A | |
| SCHEMBL8385005 | 0.80 | LTB4R (0.49) | — | |
| SCHEMBL8381057 | 0.79 | LMNA (0.52) | LTA4HSMN1; SMN2KIF11 | |
| SCHEMBL8381308 | 0.79 | SMN1; SMN2 (0.42) | LTA4HSMN1; SMN2KIF11KCNH2KCNA3 | |
| Hydrochloric Acid SCHEMBL8381165 | 0.78 | ALDH1A1 (0.49) | LTA4HSMN1; SMN2KIF11KCNH2MEN1 | |
| SCHEMBL8616998 | 0.78 | KCNA3 (0.67) | LTA4HKCNA3 | |
| Hydrochloric Acid SCHEMBL8383473 | 0.77 | KCNH2 (0.50) | LTA4HSMN1; SMN2KIF11KCNH2MEN1 | |
| Hydrochloric Acid SCHEMBL8385020 | 0.77 | F2 (0.46) | LTA4HSMN1; SMN2KIF11KCNH2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874436-A | EFFECTIVE IN INHIBITING THE ACTION OF A BACTERIAL HISTIDINE PROTEIN KINASE; USEFUL AGAINST ANTIBIOTIC RESISTANT ORGANISMS | DEMERS JAMES P (US) | 1999-02-23 | — | — | US | disclosed |
| WO-1997048676-A1 | TRIPHENYLALKYL ANTIMICROBIAL AGENTS | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-12-24 | — | — | WO | disclosed |
| US-5643950-A | INHIBITORS OF A BACTERIAL HISTIDINE PROTEIN KINASE | ORTHO PHARMACEUTICAL CORPORATION (US) | 1997-07-01 | — | — | US | disclosed |