Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 4/20 | 0.53 |
| ▸ | GRM5 | P41594 | 1/20 | 0.50 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.47 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.38 |
| ▸ | FEN1 | P39748 | 2/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | F3 | P13726 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | PNMT | P11086 | 1/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | DRD4 | P21917 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31000386 | 0.89 | NNMT (0.55) | NNMTGRM5ASIC3PIK3CDPIK3C3 | |
| SCHEMBL21573715 | 0.80 | NNMT (0.57) | NNMTGRM5ASIC3PIK3CDPIK3C3 | |
| SCHEMBL8388712 | 0.79 | ASIC3 (0.62) | NNMTGRM5ASIC3PIK3CDPIK3C3 | |
| SCHEMBL13004722 | 0.76 | NNMT (0.53) | NNMTGRM5ASIC3PIK3CDPIK3C3 | |
| SCHEMBL1723715 | 0.76 | NNMT (0.53) | NNMTGRM5ASIC3PIK3CDPIK3C3 | |
| SCHEMBL13154323 | 0.76 | NNMT (0.57) | NNMTGRM5ASIC3PIK3CDPIK3C3 | |
| SCHEMBL10283350 | 0.76 | NNMT (0.53) | NNMTGRM5ASIC3PIK3CDPIK3C3 | |
| SCHEMBL828125 | 0.76 | NNMT (0.53) | NNMTGRM5ASIC3PIK3CDPIK3C3 | |
| SCHEMBL13538508 | 0.76 | NNMT (0.53) | NNMTGRM5ASIC3PIK3CDPIK3C3 | |
| SCHEMBL298258 | 0.76 | NNMT (0.53) | NNMTGRM5ASIC3PIK3CDPIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101402635-B | Process for producing 5-chlorine-7-aza indole | ABA CHEMICALS SHANGHAI LTD | 2011-01-12 | — | — | CN | claimed |
| CN-101402635-A | Process for producing 5-chlorine-7-aza indole | ABA CHEMICALS SHANGHAI LTD (CN) | 2009-04-08 | — | — | CN | claimed |
| CN-110128421-B | Simple preparation method of 5-halogenated-7-azaindole | 新发药业有限公司 | 2020-08-11 | — | — | CN | disclosed |
| CN-106279156-A | A kind of synthetic method of 5 chlorine 7 azaindoles | 叶芳 | 2017-01-04 | — | — | CN | disclosed |
| US-8188281-B2 | Azaindoles useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-05-29 | — | — | US | disclosed |
| US-7872018-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON, INC. (US) | 2011-01-18 | — | — | US | disclosed |
| CN-101402635-B | Process for producing 5-chlorine-7-aza indole | ABA CHEMICALS SHANGHAI LTD | 2011-01-12 | — | — | CN | disclosed |
| US-20100256365-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON, INC. | 2010-10-07 | — | — | US | disclosed |
| US-20100249118-A1 | protein kinase modulators such as Propane-1-sulfonic acid [2,4-difluoro-3-(5-ethoxy-1H-pyrrolo[1,3-b]pyridine-3-carbonyl)-phenyl]-amide, used to regulate signal transduction cascades, involved in the control of physiological functions including cellular growth and proliferation; anticarcinogenic agents | PLEXXIKON INC. | 2010-09-30 | — | — | US | disclosed |
| US-20090176763-A1 | Azaindoles useful as inhibitors of JAK and other protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2009-07-09 | — | — | US | disclosed |
| CN-101402635-A | Process for producing 5-chlorine-7-aza indole | ABA CHEMICALS SHANGHAI LTD (CN) | 2009-04-08 | — | — | CN | disclosed |
| US-7507826-B2 | Such as 3-(2-Methanesulfonyl-pyrimidin-4-yl)-5-pyridin-3-yl-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine; heart disease, diabetes, Alzheimer's disease, immunodeficiency disorders, inflammatory diseases, hypertension, allergic diseases, autoimmune diseases, destructive bone disorders | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-03-24 | — | — | US | disclosed |
| US-20080221148-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC | 2008-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249118-A1 | protein kinase modulators such as Propane-1-sulfonic acid [2,4-difluoro-3-(5-ethoxy-1H-pyrrolo[1,3-b]pyridine-3-carbonyl)-phenyl]-amide, used to regulate signal transduction cascades, involved in the control of physiological functions including cellular growth and proliferation; anticarcinogenic agents | MAP4K1, MAP4K2, MAP3K1 | NNMT 1535/4885GRM5 3903/4885ASIC3 4092/4885 |
| US-20090176763-A1 | Azaindoles useful as inhibitors of JAK and other protein kinases | JAK3, JAK2, JAK1 | NNMT 920/4885GRM5 2623/4885ASIC3 3350/4885 |
| US-20080221148-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | MAP3K20, MAP3K13, MAP3K8 | NNMT 817/4885GRM5 4037/4885ASIC3 4358/4885 |
| US-20100256365-A1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | MAP3K20, MAP3K13, MAP3K8 | NNMT 817/4885GRM5 4037/4885ASIC3 4358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.