SCHEMBL1723715

SCHEMBL1723715

Fc1cnc2c(c1)CCN2

nearest known ligand 0.53

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
NNMT P40261 4/20 0.53
GRM5 P41594 2/20 0.50
ASIC3 Q9UHC3 1/20 0.47
FEN1 P39748 4/20 0.44
ALOX5AP P20292 3/20 0.44
PIK3C3 Q8NEB9 1/20 0.40
PARP10 Q53GL7 3/20 0.37
PARP1 P09874 1/20 0.37
PIK3CD O00329 1/20 0.36
ADORA2A P29274 1/20 0.34
ABL1 P00519 1/20 0.34
PARP11 Q9NR21 2/20 0.31
MAP3K12 Q12852 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10293323 0.79 ASIC3 (0.62) NNMTGRM5ASIC3FEN1ALOX5AP
SCHEMBL12131981 0.77 NNMT (0.43) NNMTGRM5ASIC3FEN1ALOX5AP
SCHEMBL13004722 0.76 NNMT (0.53) NNMTGRM5ASIC3FEN1ALOX5AP
SCHEMBL828125 0.76 NNMT (0.53) NNMTGRM5ASIC3FEN1ALOX5AP
SCHEMBL13538508 0.76 NNMT (0.53) NNMTGRM5ASIC3FEN1ALOX5AP
SCHEMBL10283350 0.76 NNMT (0.53) NNMTGRM5ASIC3FEN1ALOX5AP
SCHEMBL8385272 0.76 NNMT (0.53) NNMTGRM5ASIC3FEN1ALOX5AP
SCHEMBL13154323 0.76 NNMT (0.57) NNMTGRM5ASIC3FEN1ALOX5AP
SCHEMBL21573715 0.76 NNMT (0.57) NNMTGRM5ASIC3FEN1ALOX5AP
SCHEMBL298258 0.76 NNMT (0.53) NNMTGRM5ASIC3FEN1ALOX5AP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12624024-B2 EP2 antagonist compounds RESERVOIR NEUROSCIENCE, INC. (US) 2026-05-12 US disclosed
US-20240182459-A1 EP2 ANTAGONIST COMPOUNDS RESERVOIR NEUROSCIENCE, INC. 2024-06-06 US disclosed
EP-4359392-A1 EP2 ANTAGONIST COMPOUNDS Reservoir Neuroscience, Inc. (US) 2024-05-01 EP disclosed
WO-2022272060-A1 EP2 ANTAGONIST COMPOUNDS RESERVOIR NEUROSCIENCE, INC. (US) 2022-12-29 WO disclosed
EP-2404922-B1 QUINOXALINE COMPOUNDS ASTELLAS PHARMA INC (JP) 2016-11-09 EP disclosed
US-8674096-B2 Substituted imidazo[1,5-a]quinoxalin-4-ones as phosphodiesterase 9 inhibitors ASTELLAS PHARMA INC. (JP) 2014-03-18 US disclosed
US-20130085134-A1 QUINOXALINE COMPOUND ASTELLAS PHARMA INC. (JP) 2013-04-04 US disclosed
US-20130085134-A1 QUINOXALINE COMPOUND ASTELLAS PHARMA INC. (JP) 2013-04-04 US disclosed
US-8357688-B2 Substituted imidazo[1,5-a]quinoxalin-4(5H)-ones as PDE9 inhibitors ASTELLAS PHARMA INC. (JP) 2013-01-22 US disclosed
US-8357688-B2 Substituted imidazo[1,5-a]quinoxalin-4(5H)-ones as PDE9 inhibitors ASTELLAS PHARMA INC. (JP) 2013-01-22 US disclosed
US-20120053177-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR PLEXXIKON INC. 2012-03-01 US disclosed
CN-102341399-A Quinoxaline compounds ASTELLAS PHARMA INC 2012-02-01 CN disclosed
EP-2404922-A1 QUINOXALINE COMPOUNDS Astellas Pharma Inc. (JP) 2012-01-11 EP disclosed
US-20110319385-A1 QUINOXALINE COMPOUND ASTELLAS PHARMA INC. (JP) 2011-12-29 US disclosed
US-20110319385-A1 QUINOXALINE COMPOUND ASTELLAS PHARMA INC. (JP) 2011-12-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120053177-A1 COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR MAP3K20, MAP3K13, MAP3K8 NNMT 817/4885GRM5 4037/4885ASIC3 4358/4885
US-20130085134-A1 QUINOXALINE COMPOUND PDE9A, PDE2A, PDE3A NNMT 277/4885GRM5 3266/4885ASIC3 2431/4885
US-12624024-B2 EP2 antagonist compounds PTGER1, PTGER2, PTGER4 NNMT 3944/4885GRM5 1046/4885ASIC3 1189/4885
US-20240182459-A1 EP2 ANTAGONIST COMPOUNDS PTGER2, PTGER1, PTGES2 NNMT 3032/4885GRM5 369/4885ASIC3 1432/4885
US-20110319385-A1 QUINOXALINE COMPOUND PDE9A, PDE5A, PDE3A NNMT 271/4885GRM5 3821/4885ASIC3 1511/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.